[HTML][HTML] Global gene expression profiling of healthy human brain and its application in studying neurological disorders
Brain function is governed by precise regulation of gene expression across its anatomically
distinct structures; however, the expression patterns of genes across hundreds of brain …
distinct structures; however, the expression patterns of genes across hundreds of brain …
[HTML][HTML] Neuron-enriched gene expression patterns are regionally anti-correlated with oligodendrocyte-enriched patterns in the adult mouse and human brain
An important goal in neuroscience is to understand gene expression patterns in the brain.
The recent availability of comprehensive and detailed expression atlases for mouse and …
The recent availability of comprehensive and detailed expression atlases for mouse and …
Overcoming bias in gene-set enrichment analyses of brain-wide transcriptomic data
The recent availability of whole-brain atlases of gene expression, which quantify the
transcriptional activity of thousands of genes across many different brain regions, has …
transcriptional activity of thousands of genes across many different brain regions, has …
Quantitative gene expression profiling of mouse brain regions reveals differential transcripts conserved in human and affected in disease models
C Brochier, MC Gaillard, E Diguet… - Physiological …, 2008 - journals.physiology.org
Using serial analysis of gene expression, we collected quantitative transcriptome data in 11
regions of the adult wild-type mouse brain: the orbital, prelimbic, cingulate, motor …
regions of the adult wild-type mouse brain: the orbital, prelimbic, cingulate, motor …
The Allen Human Brain Atlas: comprehensive gene expression mapping of the human brain
EH Shen, CC Overly, AR Jones - Trends in neurosciences, 2012 - cell.com
The Allen Human Brain Atlas is a freely available multimodal atlas of gene expression and
anatomy comprising a comprehensive 'all genes–all structures' array-based dataset of gene …
anatomy comprising a comprehensive 'all genes–all structures' array-based dataset of gene …
Neural system-enriched gene expression: relationship to biological pathways and neurological diseases
To understand the commitment of the genome to nervous system differentiation and function,
we sought to compare nervous system gene expression to that of a wide variety of other …
we sought to compare nervous system gene expression to that of a wide variety of other …
[HTML][HTML] A comparison of anatomic and cellular transcriptome structures across 40 human brain diseases
Genes associated with risk for brain disease exhibit characteristic expression patterns that
reflect both anatomical and cell type relationships. Brain-wide transcriptomic patterns of …
reflect both anatomical and cell type relationships. Brain-wide transcriptomic patterns of …
[HTML][HTML] Evolutionary conservation and divergence of the human brain transcriptome
WG Pembroke, CL Hartl, DH Geschwind - Genome biology, 2021 - Springer
Background Mouse models have allowed for the direct interrogation of genetic effects on
molecular, physiological, and behavioral brain phenotypes. However, it is unknown to what …
molecular, physiological, and behavioral brain phenotypes. However, it is unknown to what …
A tool for identification of genes expressed in patterns of interest using the Allen Brain Atlas
Motivation: Gene expression patterns can be useful in understanding the structural
organization of the brain and the regulatory logic that governs its myriad cell types. A …
organization of the brain and the regulatory logic that governs its myriad cell types. A …
ZEBRA: a hierarchically integrated gene expression atlas of the murine and human brain at single-cell resolution
The molecular causes and mechanisms of neurodegenerative diseases remain poorly
understood. A growing number of single-cell studies have implicated various neural, glial …
understood. A growing number of single-cell studies have implicated various neural, glial …