Background There is controversy about the value of evidence about the effectiveness of
healthcare interventions from non-randomised study designs. Advocates for quasi …

The design of randomised controlled trials (RCTs) should incorporate characteristics (such
as concealment of randomised allocation and blinding of participants and personnel) that …

OBJECTIVES: To consider methods and related evidence for evaluating bias in non-
randomised intervention studies. DATA SOURCES: Systematic reviews and methodological …

Background When designing a randomised controlled trial (RCT), an important
consideration is the sample size required. This is calculated from several components; one …

Background Researchers and organizations often use evidence from randomized controlled
trials (RCTs) to determine the efficacy of a treatment or intervention under ideal conditions …

Objectives The aim of the study was to extend a previously published checklist of study
design features to include study designs often used by health systems researchers and …

OBJECTIVE: To test the feasibility of creating a valid and reliable checklist with the following
features: appropriate for assessing both randomised and non-randomised studies; provision …

Background The randomised controlled trial (RCT) is the most valid design for evaluating
the relative efficacy of healthcare technology. However, many competing interventions have …

The book's subtitle sets the tone. Born of the author's struggle to find, understand, interpret,
and use randomised controlled trials, this book is the fruit of years of jotting down questions …

Non‐randomized studies may provide valuable evidence on the effects of interventions.
They are the main source of evidence on the intended effects of some types of interventions …