Objective To assess the influence of trial sample size on treatment effect estimates within
meta-analyses. Design Meta-epidemiological study. Data sources 93 meta-analyses (735 …

Recent years have seen increasing interest in and attention to evidence-based practices,
where the “evidence” generally comes from well-conducted randomized trials. However …

In 2005, the Agency for Healthcare Research and Quality established the Effective Health
Care (EHC) Program. The EHC Program aims to provide understandable and actionable …

Objective: The objective of this study was to build on the seminal paper by Tunis et al
(Practical clinical trials. Increasing the value of clinical research for decision making in …

Doctors, patients, and other decision makers need access to the best available clinical
evidence, which can come from systematic reviews, experimental trials, and observational …

Background Regarding the analysis of RCT data there is a debate going on whether an
adjustment for the baseline value of the outcome variable should be made. When an …

Background In non-randomised evaluations of public-health interventions, statistical
methods to control confounding will usually be required. We review approaches to the …

Objectives Rigorous and transparent bias assessment is a core component of high-quality
systematic reviews. We assess modifications to existing risk of bias approaches to …

Background There is little published guidance as to the sample size required for a pilot or
feasibility trial despite the fact that a sample size justification is a key element in the design …

Background Substantial amounts of public funds are invested in health research worldwide.
Publicly funded randomised controlled trials (RCTs) often recruit participants at a slower …