Mitochondrial respiration is responsible for more than 90% of oxygen consumption in
humans. Cells utilize oxygen as the final electron acceptor in the aerobic metabolism of …

Decreased oxygen availability (hypoxia) promotes physiological processes such as energy
metabolism, angiogenesis, cell proliferation and cell viability through the transcription factor …

Hypoxia promotes physiological processes such as energy metabolism, angiogenesis, cell
proliferation, and cell viability through the transcription factor Hypoxia Inducible Factor (HIF) …

The transcription factor HIF (hypoxia-inducible factor) has a central role in oxygen
homeostasis in animals ranging from nematode worms to man. Recent studies have shown …

Hypoxia elicits a variety of adaptive responses at the tissue level, at the cellular level, and at
the molecular level. A physiological response to hypoxia requires the existence of an O2 …

Oxygen is essential to the life of all aerobic organisms. Virtually every cell type is able to
sense a limited oxygen supply (hypoxia) and specifically to induce a set of oxygen-regulated …

This review focuses on the molecular stratagems utilized by bacteria, yeast, and mammals in
their adaptation to hypoxia. Among this broad range of organisms, changes in oxygen …

The ability to sense and respond to changes in oxygenation represents a fundamental
property of all metazoan cells. The discovery of the transcription factor HIF-1 has led to the …

While cellular responses to low oxygen (O 2) or hypoxia have been studied extensively, the
precise identity of mammalian cellular O 2 sensors remains controversial. Using murine …

It is now clear that mitochondrial defects are associated with a large variety of clinical
phenotypes. This is the result of the mitochondria's central role in energy production …