Morphological changes in the size and shape of the nucleus are highly prevalent in cancer,
but the underlying molecular mechanisms and the functional relevance remain poorly …

The nuclear lamina, a network of lamin filaments and lamin-associated proteins, is located
between the inner nuclear membrane and the peripheral chromatin. The nuclear lamina is …

Aberrations in nuclear size and shape are commonly used to identify cancerous tissue.
However, it remains unclear whether the disturbed nuclear structure directly contributes to …

Through advances in technology, the genetic basis of cancer has been investigated at the
genomic level, and many fundamental questions have begun to be addressed. Among …

Lamins are the key components of the nuclear lamina and by virtue of their interactions with
chromatin and binding partners act as regulators of cell proliferation and differentiation. Of …

Not long after the discovery of lamin proteins, it became clear that not all lamin subtypes are
ubiquitously expressed in cells and tissues. Especially, A-type lamins showed an inverse …

Dysmorphic nuclei are commonly seen in cancers and provide strong motivation for studying
in various cancer contexts the main structural proteins of nuclei, the lamins. Past studies …

Nuclear lamins are type V intermediate filament proteins that form a filamentous meshwork
beneath the inner nuclear membrane. Additionally, a sub‐population of A‐and B‐type …

The nuclear lamina is essential for the maintenance of nuclear shape and mechanics.
Mutations in lamin genes have been identified in a heterogeneous spectrum of human …

Lamins, together with the lamin-associated proteins of the inner nuclear membrane, are
structural proteins in the nucleus that mediate mechanical stress resistance. Novel findings …