Metabolic disturbances in obesity versus sleep apnoea: the importance of visceral obesity and insulin resistance

AN Vgontzas, EO Bixler… - Journal of internal …, 2003 - Wiley Online Library
Vgontzas AN, Bixler EO, Chrousos GP (Penn State College of Medicine, Hershey, PA;
National Institutes of Health, Bethesda, MD, USA). Metabolic disturbances in obesity versus …

Sleep apnea is a manifestation of the metabolic syndrome

AN Vgontzas, EO Bixler, GP Chrousos - Sleep medicine reviews, 2005 - Elsevier
Obstructive sleep apnea (OSA) is a prevalent disorder particularly among middle-aged,
obese men, although its existence in women as well as in lean individuals is increasingly …

Does obesity play a major role in the pathogenesis of sleep apnoea and its associated manifestations via inflammation, visceral adiposity, and insulin resistance?

AN Vgontzas - Archives of physiology and biochemistry, 2008 - Taylor & Francis
Despite the early recognition of the strong association between obstructive sleep apnoea
(OSA) and obesity, and OSA and cardiovascular problems, sleep apnoea has been treated …

Low sleep quality and daytime sleepiness in obese patients without obstructive sleep apnoea syndrome

O Resta, MP Foschino Barbaro… - Journal of internal …, 2003 - Wiley Online Library
Resta O, Foschino‐Barbaro MP, Bonfitto P, Giliberti T, Depalo A, Pannacciulli N, De Pergola
G (Respiratory Pathophysiology, University of Bari, School of Medicine, Bari, Italy; University …

Obstructive sleep apnoea is independently associated with an increased prevalence of metabolic syndrome

SR Coughlin, L Mawdsley, JA Mugarza… - European heart …, 2004 - academic.oup.com
Aims Obstructive sleep apnoea (OSA) is associated with increased cardiovascular morbidity
and mortality. Although it was previously assumed that this was due to its relation with …

Sleep apnea and daytime sleepiness and fatigue: relation to visceral obesity, insulin resistance, and hypercytokinemia

AN Vgontzas, DA Papanicolaou… - The Journal of …, 2000 - academic.oup.com
Sleep apnea and associated daytime sleepiness and fatigue are common manifestations of
mainly obese middle-aged men. The onset of sleep apnea peaks in middle age, and its …

Obstructive sleep apnoea syndrome impairs insulin sensitivity independently of anthropometric variables

F Tassone, F Lanfranco, L Gianotti, S Pivetti… - Clinical …, 2003 - Wiley Online Library
Summary objectives Obstructive sleep apnoea syndrome (OSAS) is strongly associated with
obesity and characterized by endocrine and metabolic changes including impairment of …

The relationship between serum cytokine levels with obesity and obstructive sleep apnea syndrome

TU Ciftci, O Kokturk, N Bukan, A Bilgihan - Cytokine, 2004 - Elsevier
Inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α)
may have a direct effect on glucose and lipid metabolism. On the other hand, it is known that …

Sleep apnea and sleep disruption in obese patients

AN Vgontzas, TL Tan, EO Bixler… - Archives of internal …, 1994 - jamanetwork.com
Objectives: To describe the frequency and severity of sleep apnea in obese patients without
a primary sleep complaint and to assess the sleep patterns of obese patients without apnea …

Obstructive sleep apnea: an unexpected cause of insulin resistance and diabetes

M Morgenstern, J Wang, N Beatty… - Endocrinology and …, 2014 - endo.theclinics.com
Obstructive sleep apnea (OSA), which results from upper airway occlusion during sleep,
affects at least 4% of men and 2% of women. 1 In addition to excessive daytime somnolence …