Highlights•IFNλs are dual function cytokines mediating antiviral activity and damage
control.•IFNλs confer initial antimicrobial protection at anatomical barriers without provoking …

Interferons (IFNs) constitute the first line of defense against microbial infections particularly
against viruses. They provide antiviral properties to cells by inducing the expression of …

Type III interferon (IFN-λ) was initially thought to have functions similar to those of the type I
interferons (IFN-α and IFN-β). New findings have indicated, however, that IFN-λ has a non …

Type I interferons (IFNs) are pro-inflammatory cytokines that are rapidly induced in different
cell types during viral infections. The consequences of type I IFN signalling include direct …

The IFNL4 gene is a recently discovered type III interferon, which in a significant fraction of
the human population harbours a frameshift mutation abolishing the IFNλ4 ORF. The …

Type I and III interferons (IFNs) activate similar downstream signaling cascades, but unlike
type I IFNs, type III IFNs (IFNλ) do not elicit strong inflammatory responses in vivo. Here, we …

Type I interferon (IFN), as its name implies,'interferes' with virus replication by activating
numerous genes. Further, virus-induced type I IFN regulates the magnitude and functions of …

Interferons (IFN s) are produced in response to virus infection and induce an antiviral state in
virtually all cell types. In addition to upregulating the transcription of genes that inhibit virus …

Interferons (IFNs) are cytokines that play a key role in innate and adaptive immune
responses. Despite the large number of immunological studies of these molecules, the …

IFNs are comprised of three families of cytokines that confer protection against pathogen
infection and uncontrolled cellular proliferation. The broad role IFNs play in innate and …