Lambda interferons come to light: dual function cytokines mediating antiviral immunity and damage control
Highlights•IFNλs are dual function cytokines mediating antiviral activity and damage
control.•IFNλs confer initial antimicrobial protection at anatomical barriers without provoking …
control.•IFNλs confer initial antimicrobial protection at anatomical barriers without provoking …
Importance of type I and III interferons at respiratory and intestinal barrier surfaces
ML Stanifer, C Guo, P Doldan, S Boulant - Frontiers in immunology, 2020 - frontiersin.org
Interferons (IFNs) constitute the first line of defense against microbial infections particularly
against viruses. They provide antiviral properties to cells by inducing the expression of …
against viruses. They provide antiviral properties to cells by inducing the expression of …
Interferon-λ orchestrates innate and adaptive mucosal immune responses
Type III interferon (IFN-λ) was initially thought to have functions similar to those of the type I
interferons (IFN-α and IFN-β). New findings have indicated, however, that IFN-λ has a non …
interferons (IFN-α and IFN-β). New findings have indicated, however, that IFN-λ has a non …
Regulation of antiviral T cell responses by type I interferons
Type I interferons (IFNs) are pro-inflammatory cytokines that are rapidly induced in different
cell types during viral infections. The consequences of type I IFN signalling include direct …
cell types during viral infections. The consequences of type I IFN signalling include direct …
Interferon lambda 4 signals via the IFNλ receptor to regulate antiviral activity against HCV and coronaviruses
OJ Hamming, E Terczyńska‐Dyla, G Vieyres… - The EMBO …, 2013 - embopress.org
The IFNL4 gene is a recently discovered type III interferon, which in a significant fraction of
the human population harbours a frameshift mutation abolishing the IFNλ4 ORF. The …
the human population harbours a frameshift mutation abolishing the IFNλ4 ORF. The …
Differential activation of the transcription factor IRF1 underlies the distinct immune responses elicited by type I and type III interferons
Type I and III interferons (IFNs) activate similar downstream signaling cascades, but unlike
type I IFNs, type III IFNs (IFNλ) do not elicit strong inflammatory responses in vivo. Here, we …
type I IFNs, type III IFNs (IFNλ) do not elicit strong inflammatory responses in vivo. Here, we …
Type I interferon modulates the battle of host immune system against viruses
YJ Seo, B Hahm - Advances in applied microbiology, 2010 - Elsevier
Type I interferon (IFN), as its name implies,'interferes' with virus replication by activating
numerous genes. Further, virus-induced type I IFN regulates the magnitude and functions of …
numerous genes. Further, virus-induced type I IFN regulates the magnitude and functions of …
Interferon induction and function at the mucosal surface
RK Durbin, SV Kotenko, JE Durbin - Immunological reviews, 2013 - Wiley Online Library
Interferons (IFN s) are produced in response to virus infection and induce an antiviral state in
virtually all cell types. In addition to upregulating the transcription of genes that inhibit virus …
virtually all cell types. In addition to upregulating the transcription of genes that inhibit virus …
[HTML][HTML] Evolutionary genetic dissection of human interferons
Interferons (IFNs) are cytokines that play a key role in innate and adaptive immune
responses. Despite the large number of immunological studies of these molecules, the …
responses. Despite the large number of immunological studies of these molecules, the …
Beyond good and evil: molecular mechanisms of type I and III IFN functions
JW Dowling, A Forero - The Journal of Immunology, 2022 - journals.aai.org
IFNs are comprised of three families of cytokines that confer protection against pathogen
infection and uncontrolled cellular proliferation. The broad role IFNs play in innate and …
infection and uncontrolled cellular proliferation. The broad role IFNs play in innate and …