Interferon-α (IFNα) and IFNβ, collectively known as type I IFNs, are the major effector
cytokines of the host immune response against viral infections. However, the production of …

Type I interferon (IFN) is a class of proinflammatory cytokines with a dual role on malignant
transformation, tumor progression, and response to therapy. On the one hand, robust, acute …

Despite development of new antiviral drugs, viral infections are still a major health problem.
The most potent antiviral defense mechanism is the innate production of type I interferon …

We report here the identification of a ligand-receptor system that, upon engagement, leads
to the establishment of an antiviral state. Three closely positioned genes on human …

Highlights•IFN-I signaling has recently been shown to contribute to viral immune
pathologies.•Elevated IFN-I signatures are found in persistent virus infections in multiple …

Type III interferons (IFN-λs) are the most recently found members of the IFN cytokine family
and engage IFNLR1 and IL10R2 receptor subunits to activate innate responses against …

Lambda interferons (IFNλs) or type III IFNs share homology, expression patterns, signaling
cascades, and antiviral functions with type I IFNs. This has complicated the unwinding of …

The innate immune response is the major front line of defense against viral infections. It
involves hundreds of genes with antiviral properties which expression is induced by type I …

Type I interferons (IFNs) are pleiotropic cytokines, initially described for their antiviral activity.
These cytokines exhibit a long record of clinical use in patients with some types of cancer …

Abstract Type III IFNs (IFN-λ/IL-28/29) are cytokines with type I IFN-like antiviral activities,
which remain poorly characterized. We herein show that most cell types expressed both …