Interferon-lambda and therapy for chronic hepatitis C virus infection
RP Donnelly, H Dickensheets, TR O'Brien - Trends in immunology, 2011 - cell.com
Interferon (IFN)-α, a type-I IFN, is widely used to treat chronic hepatitis C virus infection, but
the broad expression of IFN-α receptors often leads to adverse reactions in many organs …
the broad expression of IFN-α receptors often leads to adverse reactions in many organs …
Interferon lambda: modulating immunity in infectious diseases
M Syedbasha, A Egli - Frontiers in immunology, 2017 - frontiersin.org
Interferon lambdas (IFN-λs; IFNL1-4) modulate immunity in the context of infections and
autoimmune diseases, through a network of induced genes. IFN-λs act by binding to the …
autoimmune diseases, through a network of induced genes. IFN-λs act by binding to the …
Regulation of type I interferon responses
LB Ivashkiv, LT Donlin - Nature Reviews Immunology, 2014 - nature.com
Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the
development of innate and adaptive immune responses. Canonical type I IFN signalling …
development of innate and adaptive immune responses. Canonical type I IFN signalling …
[HTML][HTML] Type I interferon: friend or foe?
G Trinchieri - The Journal of experimental medicine, 2010 - ncbi.nlm.nih.gov
Although the role of type I interferon (IFN) in the protection against viral infections has been
known and studied for decades, its role in other immunologically relevant scenarios …
known and studied for decades, its role in other immunologically relevant scenarios …
The role of type I interferons in intestinal infection, homeostasis, and inflammation
H Cho, BL Kelsall - Immunological reviews, 2014 - Wiley Online Library
Type I interferons are a widely expressed family of effector cytokines that promote innate
antiviral and antibacterial immunity. Paradoxically, they can also suppress immune …
antiviral and antibacterial immunity. Paradoxically, they can also suppress immune …
Viral evasion strategies in type I IFN signaling–a summary of recent developments
KS Schulz, KL Mossman - Frontiers in immunology, 2016 - frontiersin.org
The immune system protects the organism against infections and the damage associated
with them. The first line of defense against pathogens is the innate immune response. In the …
with them. The first line of defense against pathogens is the innate immune response. In the …
Type I interferons in host defence and inflammatory diseases
MK Crow, L Ronnblom - Lupus Science & Medicine, 2019 - lupus.bmj.com
Type I interferons (IFN) can have dual and opposing roles in immunity, with effects that are
beneficial or detrimental to the individual depending on whether IFN pathway activation is …
beneficial or detrimental to the individual depending on whether IFN pathway activation is …
Interferons: signaling, antiviral and viral evasion
CA Bonjardim, PCP Ferreira, EG Kroon - Immunology letters, 2009 - Elsevier
Interferons (IFNs) were discovered as antiviral agents 50 years ago, and enormous progress
has been made since then. Nowadays, IFNs (specifically type I IFNs), have been ascribed as …
has been made since then. Nowadays, IFNs (specifically type I IFNs), have been ascribed as …
Viral infections activate types I and III interferon genes through a common mechanism
K Onoguchi, M Yoneyama, A Takemura, S Akira… - Journal of Biological …, 2007 - ASBMB
Viral infections trigger innate immune responses, including the production of type I
interferons (IFN-α and-β) and other proinflammatory cytokines. Novel antiviral cytokines IFN …
interferons (IFN-α and-β) and other proinflammatory cytokines. Novel antiviral cytokines IFN …
Interferons: cell signalling, immune modulation, antiviral response and virus countermeasures
S Goodbourn, L Didcock… - Journal of general …, 2000 - microbiologyresearch.org
To establish infections in vivo, viruses must replicate in the face of powerful immune defence
mechanisms including those induced by interferons (IFNs). The effectiveness of the IFN …
mechanisms including those induced by interferons (IFNs). The effectiveness of the IFN …