Interferon (IFN)-α, a type-I IFN, is widely used to treat chronic hepatitis C virus infection, but
the broad expression of IFN-α receptors often leads to adverse reactions in many organs …

Interferon lambdas (IFN-λs; IFNL1-4) modulate immunity in the context of infections and
autoimmune diseases, through a network of induced genes. IFN-λs act by binding to the …

Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the
development of innate and adaptive immune responses. Canonical type I IFN signalling …

Although the role of type I interferon (IFN) in the protection against viral infections has been
known and studied for decades, its role in other immunologically relevant scenarios …

Type I interferons are a widely expressed family of effector cytokines that promote innate
antiviral and antibacterial immunity. Paradoxically, they can also suppress immune …

The immune system protects the organism against infections and the damage associated
with them. The first line of defense against pathogens is the innate immune response. In the …

Type I interferons (IFN) can have dual and opposing roles in immunity, with effects that are
beneficial or detrimental to the individual depending on whether IFN pathway activation is …

Interferons (IFNs) were discovered as antiviral agents 50 years ago, and enormous progress
has been made since then. Nowadays, IFNs (specifically type I IFNs), have been ascribed as …

Viral infections trigger innate immune responses, including the production of type I
interferons (IFN-α and-β) and other proinflammatory cytokines. Novel antiviral cytokines IFN …

To establish infections in vivo, viruses must replicate in the face of powerful immune defence
mechanisms including those induced by interferons (IFNs). The effectiveness of the IFN …