To establish infections in vivo, viruses must replicate in the face of powerful immune defence
mechanisms including those induced by interferons (IFNs). The effectiveness of the IFN …

Virus-infected cells secrete a broad range of interferon (IFN) subtypes which in turn trigger
the synthesis of antiviral factors that confer host resistance. IFN-α, IFN-β and other type I …

Type I and type III IFNs bind to different cell-surface receptors but induce identical signal
transduction pathways, leading to the expression of antiviral host effector molecules. Despite …

Type I interferons (IFNs) include the IFN-α family of subtypes, IFN-β, IFN-ω, IFN-τ, IFN-κ, IFN-
λ, and IFN-ζ. IFN genes lack introns and encode secretory signal peptide sequences that are …

Numerous bacterial products such as lipopolysaccharide potently induce type I interferons
(IFNs); however, the contribution of this innate response to host defense against bacterial …

Alpha and beta interferons (IFN-α and IFN-β) are multifunctional cytokines that exhibit
differential activities through a common receptor composed of the subunits IFNAR1 and …

Type I interferons (IFNs), which include the IFN-α s, IFN-β, IFN-ω, IFN-κ, and IFN-τ, are an
evolutionarily conserved group of secreted cytokines that serve as potent extracellular …

Interferons (IFN) exert antiviral, immunomodulatory and cytostatic activities. IFN-α/β (type I
IFN) and IFN-λ (type III IFN) bind distinct receptors, but regulate similar sets of genes and …

Interferons (IFNs) are crucial cytokines of antimicrobial, antitumor, and immunomodulatory
activity. The three types of IFN (I, II, and III) are classified by their receptor specificity and …

The type I interferons (IFNs), IFN-α and IFN-β, are cytokines that have antiviral,
antiproliferative, and immunomodulatory activities. Data are now emerging that suggest that …