The development of novel pain therapeutics hinges on the identification and rigorous
validation of potential targets. Model organisms provide a means to test the involvement of …

Chronic pain represents a significant public health concern and current therapies do not
adequately meet patient needs. With the advent of genomic technologies, pain researchers …

Chronic pain affects approximately one in five adults, resulting in a greatly reduced quality of
life and a higher risk of developing co-morbidities such as depression. Available treatments …

Pain is the number one reason that people seek medical attention but pain is still under-and
poorly-treated world-wide. The purpose of this book is to give an up to date picture of what …

A major goal of pain research at the present time is the identification of pain genes. Such
genes have been informally defined in a number of ways, including the deletion or …

Pharmacological, surgical, psychological, and alternative medicine approaches for the
treatment of chronic pain, including neuropathic pain, provide only partial relief for most …

Chronic pain represents a major health burden; this maladaptive pain state occurs as a
consequence of hypersensitivity within the peripheral and central components of the …

The multidimensional issue of pain in relation to the need for efficient treatment has been the
focus of extensive research. Gaining insight into the molecular mechanisms of pain and …

Chronic pain, and especially persistent pain caused by an identifiable lesion to the nervous
system (neuropathic pain), is a clinical concern of intense ongoing research. There is clearly …

Pain, which afflicts up to 20% of the population at any time, provides both a massive
therapeutic challenge and a route to understanding mechanisms in the nervous system …