Background In this study, we evaluated the association between these polymorphisms and
gallstone disease using meta-analysis and compared the hepatic ABCG5/G8 mRNA …

BACKGROUND: Supersaturation of bile with cholesterol is a primary step in the formation of
cholesterol gallstones. ATP binding cassette (ABC) G5 and G8 play an important role in …

Abstract Background and Aim: The excretion of cholesterol from the liver is regulated by the
ATP‐binding cassette transporter ABCG8. A common genetic polymorphism D19H of …

Background Adenosine triphosphate-binding cassette (ABC) transporters ABCG5 and
ABCG8 are sterol export pumps regulating biliary cholesterol excretion. The formation of …

Abstract ATP Binding Cassette Transporter A4 (ABCB4) is a sterol export pump that
regulates excretion of biliary cholesterol. We tested association between ABCB4 …

Background Gallstones are abnormal masses caused by impaired metabolism of
cholesterol, bilirubin, or bile salts in the gallbladder or biliary tract. ATP-binding cassette …

Background Gallstone disease is a frequent and economically highly relevant disorder, with
cholecystectomy representing one of the most frequently performed operations world-wide …

Background: Gallbladder cancer (GBC) usually arises against the background of gallstone
disease, which may be causatively related to supersaturation of cholesterol in bile. An …

Background Gallstone disease (GD) is common but remains asymptomatic in most cases.
However, gallstones can lead to complications like choledocholithiasis or gallbladder …

Background The overexpression of the cholesterol transporter: ATP-binding cassette
transporter (ABCG8) due to the effect of ABCG8 genetic variant (rs11887534) leads to the …