Enhanced synthesis of a specific matrix metalloproteinase, MMP-2, has been demonstrated
in experimental models of ventricular failure and in cardiac extracts from patients with …

Matrix metalloproteinase-2 (MMP-2) is a central component of the response to injury in the
heart. During ischemia, MMP-2 influences ventricular performance and is a determinant of …

Cardiomyocyte hypertrophy and extracellular matrix remodeling, primarily mediated by
inflammatory cytokine-stimulated cardiac fibroblasts, are critical cellular events in cardiac …

Collagenase (matrix metalloproteinase-1, MMP-1) plays a central role in connective tissue
metabolism as the only enzyme capable of degrading interstitial collagens at neutral pH. We …

Matrix γ-carboxyglutamic acid protein (MGP) is a mineral-binding extracellular matrix protein
synthesized by vascular smooth muscle cells (VSMCs) and chondrocytes that is thought to …

Hypoxic and ischemic stresses cause a series of well documented changes in myocardial
cells and tissues, including increased anaerobic glycolysis, loss of contractility, changes in …

Activation of either muscarinic cholinergic or thrombin receptors increases phosphoinositide
turnover, Ca2+ mobilization, and redistribution of protein kinase C and induces rapid …

Matrix metalloproteinases (MMPs) are zinc-dependent proteases involved in intra-and extra-
cellular matrix remodeling resulting from oxidative stress injury to the heart. MMP-2 was the …

Electrical stimulation of contractions (pacing) of primary neonatal rat ventricular myocytes
increases intracellular calcium and activates a hypertrophic growth program that includes …

Extracellular matrix (ECM) turnover is regulated by matrix metalloproteinases (MMPs) and
plays an important role in cardiac remodeling. Previous studies from our lab demonstrated …