Recent advances in chemistry and therapeutic potential of functionalized quinoline motifs–a review

OO Ajani, KT Iyaye, OT Ademosun - RSC advances, 2022 - pubs.rsc.org
Quinoline, which consists of benzene fused with N-heterocyclic pyridine, has received
considerable attention as a core template in drug design because of its broad spectrum of …

Quinoline‐derivatives as privileged scaffolds for medicinal and pharmaceutical chemists: A comprehensive review

V Yadav, J Reang, V Sharma, J Majeed… - Chemical Biology & …, 2022 - Wiley Online Library
The quinoline scaffolds are privileged for their numerous biological activities in the
pharmaceutical field. This moiety constitutes a well‐known space in several marketed …

Exploring diverse frontiers: Advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond

L Ravindar, SA Hasbullah, KP Rakesh… - European Journal of …, 2023 - Elsevier
Amongst heterocyclic compounds, quinoline and its derivatives are advantaged scaffolds
that appear as a significant assembly motif for developing new drug entities. Aminoquinoline …

Therapeutic significance of quinolines: a patent review (2013-2015)

SMA Hussaini - Expert opinion on therapeutic patents, 2016 - Taylor & Francis
Introduction: Quinoline is a versatile bicyclic heterocyclic scaffold with immense therapeutic
potential. Some of the compounds containing quinoline nucleus are agents of choice for the …

Quinolines, a perpetual, multipurpose scaffold in medicinal chemistry

P Yadav, K Shah - Bioorganic Chemistry, 2021 - Elsevier
Quinoline is a versatile pharmacophore, a privileged scaffold and an outstanding fused
heterocyclic compound with a wide range of pharmacological prospective such as …

A comprehensive review on the biological interest of quinoline and its derivatives

BS Matada, R Pattanashettar, NG Yernale - Bioorganic & Medicinal …, 2021 - Elsevier
Amongst heterocyclic compounds, quinoline is an advantaged scaffold that appears as a
significant assembly motif for the development of new drug entities. Quinoline and its …

A review on synthetic investigation for quinoline-recent green approaches

A Patel, S Patel, M Mehta, Y Patel, R Patel… - … Chemistry Letters and …, 2022 - Taylor & Francis
Quinolines are a prominent heterocyclic motif and crucial building blocks in creating
physiologically active compounds. Due to the fast development of novel medicines with a …

Recent advances in research of natural and synthetic bioactive quinolines

PY Chung, ZX Bian, HY Pun, D Chan… - Future medicinal …, 2015 - Taylor & Francis
Many natural products that consist of quinoline core are found to be bioactive and the
versatility of quinoline and its derivatives have attracted great attention in the field of drug …

Synthetic approaches, functionalization and therapeutic potential of quinazoline and quinazolinone skeletons: The advances continue

I Khan, A Ibrar, W Ahmed, A Saeed - European journal of medicinal …, 2015 - Elsevier
The presence of N-heterocycles as an essential structural motif in a variety of biologically
active substances has stimulated the development of new strategies and technologies for …

The 4-quinolone-3-carboxylic acid motif as a multivalent scaffold in medicinal chemistry

C Mugnaini, S Pasquini, F Corelli - Current medicinal chemistry, 2009 - ingentaconnect.com
Quinolones are among the most common frameworks present in the bioactive molecules
and hence represent an attractive starting point for the design of combinatorial libraries …