Regulation of CYP1A1 by heavy metals and consequences for drug metabolism
A Anwar-Mohamed, RH Elbekai… - Expert opinion on drug …, 2009 - Taylor & Francis
Cytochrome P450 1A1 (CYP1A1) is a hepatic and extrahepatic enzyme that is regulated by
the aryl hydrocarbon receptor signaling pathway. With the growing human exposure to …
the aryl hydrocarbon receptor signaling pathway. With the growing human exposure to …
Modulation of CYP1A1 metabolism: From adverse health effects to chemoprevention and therapeutic options
M Mescher, T Haarmann-Stemmann - Pharmacology & therapeutics, 2018 - Elsevier
The human cytochrome P450 (CYP) 1A1 gene encodes a monooxygenase that metabolizes
multiple exogenous and endogenous substrates. CYP1A1 has become infamous for its …
multiple exogenous and endogenous substrates. CYP1A1 has become infamous for its …
Biological roles of cytochrome P450 1A1, 1A2, and 1B1 enzymes
YJ Kwon, S Shin, YJ Chun - Archives of pharmacal research, 2021 - Springer
Human cytochrome P450 enzymes (CYPs) play a critical role in various biological
processes and human diseases. CYP1 family members, including CYP1A1, CYP1A2, and …
processes and human diseases. CYP1 family members, including CYP1A1, CYP1A2, and …
Cytochrome P450 CYP1A1: wider roles in cancer progression and prevention
CYP1A1 is one of the main cytochrome P450 enzymes, examined extensively for its capacity
to activate compounds with carcinogenic properties. Continuous exposure to inhalation …
to activate compounds with carcinogenic properties. Continuous exposure to inhalation …
A comprehensive review of cytochrome P450 2E1 for xenobiotic metabolism
Abstract Cytochrome P450 2E1 (CYP2E1) plays a vital role in drug-induced hepatotoxicity
and cancers (eg lung and bladder cancer), since it is responsible for metabolizing a number …
and cancers (eg lung and bladder cancer), since it is responsible for metabolizing a number …
Drug–drug interactions involving intestinal and hepatic CYP1A enzymes
F Klomp, C Wenzel, M Drozdzik, S Oswald - Pharmaceutics, 2020 - mdpi.com
Cytochrome P450 (CYP) 1A enzymes are considerably expressed in the human intestine
and liver and involved in the biotransformation of about 10% of marketed drugs. Despite this …
and liver and involved in the biotransformation of about 10% of marketed drugs. Despite this …
Cytochrome P450 3A and their regulation
O Burk, L Wojnowski - Naunyn-Schmiedeberg's archives of pharmacology, 2004 - Springer
CYP3A isozymes collectively comprise the largest portion of the liver and small intestinal
CYP protein and they are involved in the metabolism of 45–60% of all currently used drugs …
CYP protein and they are involved in the metabolism of 45–60% of all currently used drugs …
Metabolism and mechanism of human cytochrome P450 enzyme 1A2
Human cytochrome P450 enzyme 1A2 (CYP1A2) is one of the most important cytochrome
P450 (CYP) enzymes in the liver, accounting for 13% to 15% of hepatic CYP enzymes …
P450 (CYP) enzymes in the liver, accounting for 13% to 15% of hepatic CYP enzymes …
CYP3A4 induction by xenobiotics: biochemistry, experimental methods and impact on drug discovery and development
G Luo, T Guenthner, LS Gan… - Current drug …, 2004 - ingentaconnect.com
Cytochrome P450 3A4 (CYP3A4), an enzyme that is highly expressed in the human liver
and small intestine, plays a major role in the metabolism of a large variety of xenobiotics …
and small intestine, plays a major role in the metabolism of a large variety of xenobiotics …
Transcriptional activation and posttranscriptional modification of Cyp1a1 by arsenite, cadmium, and chromium
RH Elbekai, AOS El-Kadi - Toxicology letters, 2007 - Elsevier
Heavy metals alter the carcinogenicity of AhR ligands by modulating the induction of the
Cyp1a1 enzyme, but the mechanism (s) remain unresolved. In this study, the effect of the …
Cyp1a1 enzyme, but the mechanism (s) remain unresolved. In this study, the effect of the …