Cystic fibrosis (CF), which is caused by mutations in CFTR, affects many tissues, including
the lung. Submucosal gland serous acinar cells are primary sites of fluid secretion and …

Alterations in epithelial secretions and mucociliary clearance contribute to chronic bacterial
infection in cystic fibrosis (CF) lung disease, but whether CF lungs are unchanged in the …

The most common mutation in the CFTR gene in individuals with cystic fibrosis (CF), ΔF508,
leads to the absence of CFTR Cl− channels in the apical plasma membrane, which in turn …

Epithelial salt and water secretion serves a variety of functions in different organ systems,
such as the airways, intestines, pancreas, and salivary glands. In cystic fibrosis (CF), the …

Submucosal glands line the cartilaginous airways and produce most of the antimicrobial
mucus that keeps the airways sterile. The glands are defective in cystic fibrosis (CF), but how …

Cystic fibrosis (CF) is the most common lethal monogenic disorder in Caucasians, estimated
to affect one out of 2500–4000 new-borns. In patients with CF, lack of CF transmembrane …

Mucus pathology in cystic fibrosis (CF) has been known for as long as the disease has been
recognized and is sometimes called mucoviscidosis. The disease is marked by mucus …

Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator
(CFTR) gene, which accounts for the cAMP-modulated chloride conductance of airway …

Cystic fibrosis is a lethal genetic disorder characterized by viscous mucus and bacterial
colonization of the airways. Airway surface liquid represents a first line of pulmonary …

Current concepts of cystic fibrosis (CF) pathophysiology link ion transport abnormalities to
reduced airway surface liquid (ASL) hydration and impaired mucus clearance. It is likely that …