Patients with cystic fibrosis have a lesion in the cystic fibrosis transmembrane conductance
regulator gene (CFTR), which is associated with abnormal regulation of other ion channels …

Human airway serous cells secrete antibiotic-rich fluid, but, in cystic fibrosis (CF), Cl−-
dependent fluid secretion is impaired by defects in CF transmembrane conductance …

Question Cystic fibrosis (CF) is characterised by the accumulation of viscous adherent
mucus in the lungs. While several hypotheses invoke a direct relationship with cystic fibrosis …

Dysfunction of CFTR in cystic fibrosis (CF) airway epithelium perturbs the normal regulation
of ion transport, leading to a reduced volume of airway surface liquid (ASL), mucus …

In developing gene therapy for cystic fibrosis (CF) airways disease, a transgene encoding a
partially deleted CF transmembrane conductance regulator (CFTR) Cl− channel could be of …

Cigarette smoke (CS) exposure induces mucus obstruction and the development of chronic
bronchitis (CB). While many of these responses are determined genetically, little is known …

Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator
(CFTR) that prevent its proper folding and trafficking to the apical membrane of epithelial …

Cystic fibrosis (CF) remains the most common life-shortening hereditary disease in white
populations, with high morbidity and mortality related to chronic airway mucus obstruction …

Cystic fibrosis (CF), the most common fatal monogenic disease in the United States, results
from mutations in CF transmembrane conductance regulator (CFTR), a chloride channel …

Background Cystic fibrosis (CF) is a syndrome caused by mutations in the cystic fibrosis
transmembrane regulator (CFTR) gene. Despite advances in our understanding of the …