To study the multifaceted biology of prostate cancer, pre-clinical in vivo models offer a range
of options to uncover critical biological information about this disease. The human orthotopic …

Our laboratory has developed a novel orthotopic implantation model of human prostate
cancer (PCa). As PCa death is not due to the primary tumor, but rather the formation of …

Orthotopic tumor modeling is a valuable tool for pre-clinical prostate cancer research, as it
has multiple advantages over both subcutaneous and transgenic genetically engineered …

In humans, the natural history of prostate cancer spans 30–40 years, which makes it a
difficult disease to model in rodents. Furthermore, the molecular pathology of prostate …

Robust preclinical models of prostate cancer are required as clinical management of men
with this disease evolves, and increasing genomic understanding makes currently available …

In vivo animal studies are an essential component of prostate cancer research, and are
particularly critical for studying interactions between tumor cells and their microenvironment …

Background There are limited preclinical orthotopic prostate cancer models due to the
technical complexity of surgical engraftment and tracking the tumor growth in the mouse …

Background Patients with advanced prostate cancer have limited curative options, therefore
new treatments are needed. Mouse models play a pivotal role in the discovery and …

Prostate cancer is one of the most common cancers in men in the United States.
Comprehensive understanding of the biology contributing to prostate cancer will have …

BACKGROUND In vivo model systems in prostate cancer research that authentically
reproduce tumor growth are still sparse. While orthotopic implantation is technically difficult …