Delivery of the 5-HT2A Receptor Agonist, DOI, Enhances Activity of the Sphincter Muscle during the Micturition Reflex in Rats after Spinal Cord Injury
JH DeFinis, J Weinberger, S Hou - Biology, 2021 - mdpi.com
Simple Summary Spinal cord injury often disrupts connections between the brain and spinal
cord leading to a plethora of health complications, including bladder dysfunction. Spinal …
cord leading to a plethora of health complications, including bladder dysfunction. Spinal …
Upregulated 5-HT1A Receptors Regulate Lower Urinary Tract Function in Rats after Complete Spinal Cord Injury
CY Lin, K Li, R Thalluri, YS Lee - Journal of Neurotrauma, 2023 - liebertpub.com
Spinal cord injury (SCI) above the lumbosacral level often leads to dysfunction of the lower
urinary tract (LUT) including detrusor hyper-reflexia, wherein bladder compliance is low …
urinary tract (LUT) including detrusor hyper-reflexia, wherein bladder compliance is low …
Improvement of lower urinary tract function by a selective serotonin 5-HT1A receptor agonist, NLX-112, after chronic spinal cord injury
CY Lin, A Sparks, YS Lee - Experimental neurology, 2020 - Elsevier
Spinal cord injury (SCI) above the lumbosacral level results in lower urinary tract
dysfunction, including (1) detrusor hyperreflexia, wherein bladder compliance is low, and (2) …
dysfunction, including (1) detrusor hyperreflexia, wherein bladder compliance is low, and (2) …
Improving voiding efficiency in the diabetic rat by a 5‐HT1A serotonin receptor agonist
B Gu, G Wu, J Si, Y Xu… - Neurourology and …, 2012 - Wiley Online Library
Aims Serotonin affects micturition in the normal rat through actions not only on ascending
and descending spinal pathways and supraspinal centers but also on the lumbosacral …
and descending spinal pathways and supraspinal centers but also on the lumbosacral …
Fluoxetine, a selective serotonin reuptake inhibitor used clinically, improves bladder function in a mouse model of moderate spinal cord injury
L Ma, JY Tang, JY Zhou, C Zhu, X Zhang… - Neural Regeneration …, 2021 - journals.lww.com
After spinal cord injury, the upward conduction of the spinal cord is lost, resulting in the loss
of micturition control, which manifests as detrusor sphincter dyssynergia and insufficient …
of micturition control, which manifests as detrusor sphincter dyssynergia and insufficient …
Chronic spinal cord injury causes upregulation of serotonin (5‐HT)2A and 5‐HT2C receptors in lumbosacral cord motoneurons
N Cao, J Ni, X Wang, H Tu, B Gu, J Si, G Wu… - BJU …, 2018 - Wiley Online Library
Objectives To investigate whether the voiding dysfunction caused by spinal cord injury (SCI)
in rats can be improved by iv administration of the serotonin (5‐HT) 2A/2C receptor agonist …
in rats can be improved by iv administration of the serotonin (5‐HT) 2A/2C receptor agonist …
Role of Central 5‐Hydroxytryptamine Receptors in Micturition Control
H Kakizaki, M Yoshiyama - LUTS: Lower Urinary Tract …, 2009 - Wiley Online Library
5‐Hydroxytryptamine (5‐HT) receptors in the central nervous system have been implicated
in the control of micturition. In rats and cats, spinal and supraspinal reflex pathways involved …
in the control of micturition. In rats and cats, spinal and supraspinal reflex pathways involved …
Effect of 5-Hydroxytryptamine1 Serotonin Receptor Agonists on Noxiously Stimulated Micturition in Cats With Chronic Spinal Cord Injury
Purpose: The serotonin 5-hydroxytryptamine1A/7 receptor agonist (R)-8-OH-DPAT (8-
hydroxy-2-(di-n-propylamino) tetralin)(Sigma®) and the 5-hydroxytryptamine1A/1B/1D …
hydroxy-2-(di-n-propylamino) tetralin)(Sigma®) and the 5-hydroxytryptamine1A/1B/1D …
Altered glutamate receptor function during recovery of bladder detrusor-external urethral sphincter coordination in a rat model of spinal cord injury
V Pikov, JR Wrathall - Journal of Pharmacology and Experimental …, 2002 - ASPET
Coordination of the bladder detrusor and the external urethral sphincter is a supraspinally
controlled reflex that is essential for efficient micturition. This coordination is permanently lost …
controlled reflex that is essential for efficient micturition. This coordination is permanently lost …
The effect of the 5‐HT7 serotonin receptor agonist, LP44, on micturition in rats with chronic spinal cord injury
W Gang, T Hongjian, C Jasheng… - Neurourology and …, 2014 - Wiley Online Library
Aims To better understand the effects of the selective 5‐HT7 receptor agonist 4‐[2‐
(Methylthio) phenyl]‐N‐(1, 2, 3, 4‐tetrahydro‐1‐naphthalenyl)‐1‐piperazinehexanamide …
(Methylthio) phenyl]‐N‐(1, 2, 3, 4‐tetrahydro‐1‐naphthalenyl)‐1‐piperazinehexanamide …
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