Alzheimer's disease (AD) is a multifactorial disorder characterized by exponential loss of
memory and cognitive deficit involving several disease modifying targets (amyloid beta, beta …

Multifactorial neurodegenerative disorders such as Alzheimer's disease (AD) are considered
a growing public health problem due the rising incidence and low effectiveness of current …

Alzheimer's disease (AD) is a complex disorder and the disease mechanism is yet to be
properly characterized. Over the years,“amyloid cascade” emerges as principal pathogenic …

Alzhemier's disease (AD) is a common form of dementia in the ageing population which is
characterized by depositions of amyloids and a cholinergic neurotransmission deficit in the …

Neurodegenerative diseases are characterized by the progressive and irreversible loss of
neurons from specific regions of the brain. The pattern of neuronal loss is selective, affecting …

Alzheimer's disease (AD) is a multifactorial neurodegenerative condition of the central
nervous system (CNS) that is currently treated by cholinesterase inhibitors and the N-methyl …

Alzheimer's disease (AD) is characterized by depositions of amyloid β (Aβ) peptides
aggregates resulting in plaques formation in the central nervous system (CNS). This study …

A novel series of aromatic esters (1a-1m) related to the Amaryllidaceae alkaloid (AA)
haemanthamine were designed, synthesized and tested in vitro with particular emphasis on …

A series of homoisoflavonoid derivatives was designed, synthesized and evaluated as
potential multi-functional anti-Alzheimer's agents for their inhibitory activity on cholinesterase …

Currently, acetylcholinesterase (AChE) inhibiting drugs in clinical use, such as tacrine,
donepezil, rivastigmine, and galanthamine, are associated with serious side effects and …