Aripiprazole and Dehydro-Aripiprazole Solid Solutions: Crystalline Combinations of Drug and Active Metabolite in Tailored Compositions
JT Trotta, TA Zeidan, PA Tilak, BM Foxman… - Crystal Growth & …, 2020 - ACS Publications
Solid solutions of aripiprazole (APZ) and its active metabolite, dehydro-aripiprazole (dAPZ),
have been prepared as free form (neat or nonsolvated), hydrated, or alcohol-solvated …
have been prepared as free form (neat or nonsolvated), hydrated, or alcohol-solvated …
Aripiprazole: polymorphs and solvatomorphs
HG Brittain - Profiles of Drug Substances, Excipients and Related …, 2012 - Elsevier
The polymorphic (crystal systems for which a substance can exist in structures defined by
different unit cells, and where each of the forms has the same elemental composition) and …
different unit cells, and where each of the forms has the same elemental composition) and …
Low-temperature phase transition in crystalline aripiprazole leads to an eighth polymorph
SP Delaney, TM Smith, D Pan, SX Yin… - Crystal growth & …, 2014 - ACS Publications
A new crystalline polymorph (Form VIII) of the antidepressant drug aripiprazole has been
discovered, resulting from a previously unknown enantiotropic phase transition from Form II …
discovered, resulting from a previously unknown enantiotropic phase transition from Form II …
Polymorphism of dehydro-aripiprazole, the active metabolite of the antipsychotic drug aripiprazole (abilify)
TA Zeidan, JT Trotta, RA Chiarella… - Crystal growth & …, 2013 - ACS Publications
Crystal form exploration of dehydro-aripiprazole (dAPZ), the active metabolite of the
antipsychotic drug aripiprazole (APZ), elucidated five polymorphs (I, II, III, IV, and V), two …
antipsychotic drug aripiprazole (APZ), elucidated five polymorphs (I, II, III, IV, and V), two …
Morphological and crystalline transitions in monohydrous and anhydrous aripiprazole for a long-acting injectable suspension
X Tan, Y Zhong, L He, Y Zhang, G Jing, S Li, J Wang… - AAPS …, 2017 - Springer
Many formulation and manufacturing processes can lead to morphological and crystalline
transitions in many polycrystalline drugs, changing the properties of active pharmaceutical …
transitions in many polycrystalline drugs, changing the properties of active pharmaceutical …
Solution-mediated phase transformation of aripiprazole: Negating the effect of crystalline forms on dissolution and oral pharmacokinetics
S Chung, J Kim, E Ban, J Yun, B Park, A Kim - Journal of Pharmaceutical …, 2020 - Elsevier
We aimed to evaluate the effect of crystalline forms of aripiprazole, an antipsychotic drug for
schizophrenia, on the dissolution rates and oral pharmacokinetics. Solubility, intrinsic …
schizophrenia, on the dissolution rates and oral pharmacokinetics. Solubility, intrinsic …
Tuning physicochemical properties of antipsychotic drug aripiprazole with multicomponent crystal strategy based on structure and property relationship
Y Zhao, B Sun, L Jia, Y Wang, M Wang… - Crystal Growth & …, 2020 - ACS Publications
Poor solubility and dissolution property of pharmaceuticals largely limits their bioavailability
and efficacy, and development of a multicomponent crystal is one of the effective …
and efficacy, and development of a multicomponent crystal is one of the effective …
Correlating the melting point alteration with the supramolecular structure in aripiprazole drug cocrystals
JB Nanubolu, K Ravikumar - CrystEngComm, 2016 - pubs.rsc.org
Five novel cocrystals of antipsychotic drug aripiprazole are reported with dihydroxy-and
trihydroxybenzene coformers. The cocrystals are designed by exploiting the piperazine N …
trihydroxybenzene coformers. The cocrystals are designed by exploiting the piperazine N …
Stability of solvates and packing systematics of nine crystal forms of the antipsychotic drug aripiprazole
DE Braun, T Gelbrich, V Kahlenberg… - Crystal Growth and …, 2009 - ACS Publications
A comprehensive characterization (thermal, spectroscopic, crystallographic, temperature-
and moisture-dependent stability, and transition characteristics) of solvates of aripiprazole …
and moisture-dependent stability, and transition characteristics) of solvates of aripiprazole …
[HTML][HTML] New cocrystals of antipsychotic drug aripiprazole: decreasing the dissolution through cocrystallization
W Liu, R Ma, F Liang, C Duan, G Zhang, Y Chen… - Molecules, 2021 - mdpi.com
Cocrystallization is an important route to tuning the solubility in drugs development,
including improving and reducing. Five cocrystals of aripiprazole (ARI) with resveratrol …
including improving and reducing. Five cocrystals of aripiprazole (ARI) with resveratrol …
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