Ischemia–reperfusion is a major component of injury in vascular occlusion both during liver
surgery and during liver transplantation. The pathophysiology of hepatic ischemia …

Oxidative stress is an important factor in many pathological conditions such as inflammation,
cancer, ageing and organ response to ischemia‐reperfusion. Humans have developed a …

In response to stress signal, nuclear factor‐erythroid 2‐related factor 2 (Nrf2) induces the
expression of target genes involved in antioxidant defense and detoxification. Nrf2 activity is …

Increasing evidence has shown that reactive oxygen species (ROS) are important mediators
in liver ischemia/reperfusion injury (IRI). ROS include hydrogen peroxide (H2O2) …

Ischemia-reperfusion injury is, at least in part, responsible for the morbidity associated with
liver surgery under total vascular exclusion or after liver transplantation. The …

Abstract Ischemia/reperfusion (I/R) injury associated with hepatic resections and liver
transplantation remains a serious complication in clinical practice, despite several attempts …

Abstract Reactive Oxygen Species (ROS) are key mediators of ischemia-reperfusion injury
but also required for the induction of the stress response that limits tissue injury and …

Hepatic ischemia-reperfusion injury is a major cause of post-operative hepatic dysfunction
and liver failure after transplantation. This review summarizes the mechanisms of ischemia …

Ischemia/reperfusion injury is an inevitable process during liver transplantation and can lead
to a high incidence of early allograft dysfunction and graft failure. The mechanism of hepatic …

Ischemia/reperfusion (I/R) injury is a multifactorial process that affects graft function after liver
transplantation. An understanding of the mechanisms involved in I/R injury is essential for …