Endoplasmic reticulum stress as the basis of obesity and metabolic diseases: focus on adipose tissue, liver, and pancreas
A Fernandes-da-Silva, CS Miranda… - European journal of …, 2021 - Springer
Obesity challenges lipid and carbohydrate metabolism. The resulting glucolipotoxicity
causes endoplasmic reticulum (ER) dysfunction, provoking the accumulation of immature …
causes endoplasmic reticulum (ER) dysfunction, provoking the accumulation of immature …
ER stress in obesity pathogenesis and management
A Ajoolabady, S Liu, DJ Klionsky, GYH Lip… - Trends in …, 2022 - cell.com
Given the unprecedented global pandemic of obesity, a better understanding of the etiology
of adiposity will be necessary to ensure effective management of obesity and related …
of adiposity will be necessary to ensure effective management of obesity and related …
[HTML][HTML] Endoplasmic reticulum stress in metabolic disorders
R Ghemrawi, SF Battaglia-Hsu, C Arnold - Cells, 2018 - mdpi.com
Metabolic disorders have become among the most serious threats to human health, leading
to severe chronic diseases such as obesity, type 2 diabetes, and non-alcoholic fatty liver …
to severe chronic diseases such as obesity, type 2 diabetes, and non-alcoholic fatty liver …
Endoplasmic reticulum stress and obesity
E Yilmaz - Obesity and lipotoxicity, 2017 - Springer
In recent years, the world has seen an alarming increase in obesity and closely associated
with insulin resistance which is a state of low-grade inflammation, the latter characterized by …
with insulin resistance which is a state of low-grade inflammation, the latter characterized by …
Endoplasmic reticulum stress in obesity and obesity-related disorders: An expanded view
MJ Pagliassotti, PY Kim, AL Estrada, CM Stewart… - Metabolism, 2016 - Elsevier
The endoplasmic reticulum (ER) is most notable for its central roles in calcium ion storage,
lipid biosynthesis, and protein sorting and processing. By virtue of its extensive membrane …
lipid biosynthesis, and protein sorting and processing. By virtue of its extensive membrane …
[HTML][HTML] A guide to understanding endoplasmic reticulum stress in metabolic disorders
IL Lemmer, N Willemsen, N Hilal, A Bartelt - Molecular metabolism, 2021 - Elsevier
Background The global rise of metabolic disorders, such as obesity, type 2 diabetes, and
cardiovascular disease, demands a thorough molecular understanding of the cellular …
cardiovascular disease, demands a thorough molecular understanding of the cellular …
Endoplasmic reticulum stress, obesity and diabetes
M Cnop, F Foufelle, LA Velloso - Trends in molecular medicine, 2012 - cell.com
The endoplasmic reticulum (ER) stress response, also commonly known as the unfolded
protein response (UPR), is an adaptive response used to align ER functional capacity with …
protein response (UPR), is an adaptive response used to align ER functional capacity with …
New insights into ER stress-induced insulin resistance
Insulin resistance is a major characteristic of obesity and type 2 diabetes (T2DM). During the
last decade, endoplasmic reticulum (ER) stress has emerged as a new player in this field …
last decade, endoplasmic reticulum (ER) stress has emerged as a new player in this field …
Mechanism of ER stress and inflammation for hepatic insulin resistance in obesity
OK Kim, W Jun, J Lee - Annals of Nutrition and Metabolism, 2015 - karger.com
Background: Obesity is a major risk factor in the development of hepatic insulin resistance,
which is characterized by an impairment of insulin ability to inhibit glucose output. Although …
which is characterized by an impairment of insulin ability to inhibit glucose output. Although …
ER stress and lipid metabolism in adipocytes
BS Zha, H Zhou - Biochemistry research international, 2012 - Wiley Online Library
The role of endoplasmic reticulum (ER) stress is a rapidly emerging field of interest in the
pathogenesis of metabolic diseases. Recent studies have shown that chronic activation of …
pathogenesis of metabolic diseases. Recent studies have shown that chronic activation of …