Cells encountering hostile growth conditions, like those residing in the middle of a newly
developing solid tumor, conserve resources and energy by downregulating protein …

Upon cell-cycle arrest or nutrient deprivation, the cellular rate of ribosome production is
reduced significantly. In mammalian cells, this effect is achieved in part through a co …

Translation of terminal oligopyrimidine tract (TOP) mRNAs, which encode multiple
components of the protein synthesis machinery, is known to be controlled by mitogenic …

The synthesis of many mammalian proteins associated with the translational apparatus is
selectively regulated by mitogenic and nutritional stimuli, at the translational level. The …

The response of cells to changes in their environment often requires coregulation of gene
networks, but little is known about how this can occur at the post-transcriptional level. An …

Cells encountering hypoxic stress conserve resources and energy by downregulating the
protein synthesis. Here we demonstrate that one mechanism in this response is the …

TOP mRNAs are vertebrate transcripts which contain a 5′ terminal oligopyrimidine tract
(5′ TOP), encode for ribosomal proteins and elongation factors 1α and 2, and are …

Vertebrate TOP mRNAs contain an oligopyrimidine tract at their 5′ termini (5′ TOP) and
encode components of the translational machinery. Previously it has been shown that they …

Although the knowledge accumulated on the transcriptional regulations of eukaryotes is
significant, the knowledge on their translational regulations remains limited. Thus, we …

The stimulatory effect of insulin on protein synthesis is due to its ability to activate various
translation factors. We now show that insulin can increase protein synthesis capacity also by …