Introduction 3. The T box system 3.1. A conserved pattern in T box family leader RNAs 3.1. 1.
A single codon provides the basis for amino acid-specific regulation 3.1. 2. The codon …

The link between perturbations in translational control and cancer etiology is becoming a
primary focus in cancer research. It has now been established that genetic alterations in …

Translation of 5′ terminal oligopyrimidine (TOP) mRNAs encoding the protein synthesis
machinery is strictly regulated by an amino-acid-sensing mTOR pathway. However, its …

Control of translation initiation is an important means by which cells tightly regulate the
critical processes of growth and proliferation. Multiple effector proteins contribute to …

Protein synthesis can be segmented into distinct phases comprising mRNA translation
initiation, elongation, and termination. Translation initiation is a highly regulated and rate …

Post-transcriptional regulation of gene expression plays important roles in diverse cellular
processes such as development, metabolism and cancer progression. Whereas many …

Summry—Deregulation of gene expression is a hallmark of the cancer cell. Acquiring a new
profile of expressed proteins may enable the cell to re‐enter the cell cycle, or give them a …

Mammalian stress granules (SGs) are cytoplasmic domains into which mRNAs are sorted
dynamically in response to phosphorylation of eukaryotic initiation factor (eIF) 2α, a key …

Recent work has shown that RNA polymerase (Pol) II can be recruited to and transcribe
distal regulatory regions. Here we analyzed transcription initiation and elongation through …

Tumor cells are continually subjected to diverse stress conditions of the tumor
microenvironment, including hypoxia, nutrient deprivation, and oxidative or genotoxic stress …