Successful recovery from lung injury requires the repair and regeneration of alveolar
epithelial cells to restore the integrity of gas-exchanging regions within the lung and …

Mechanisms that regulate inflammation and repair after acute lung injury are incompletely
understood. The extracellular matrix glycosaminoglycan hyaluronan is produced after tissue …

Although the lung can undergo self-repair after injury, fibrosis in chronically injured or
diseased lungs can occur at the expense of regeneration. Here we study how a …

Functional tissue regeneration is required for the restoration of normal organ homeostasis
after severe injury. Some organs, such as the intestine, harbour active stem cells throughout …

Lung diseases such as chronic obstructive pulmonary disease and pulmonary fibrosis
involve the progressive and inexorable destruction of oxygen exchange surfaces and …

Mechanisms that regulate host defense after noninfectious tissue injury are incompletely
understood. Our laboratory is interested in the role of the extracellular matrix …

Fibroblasts are present throughout the body and function to maintain tissue homeostasis.
Recent studies have identified diverse fibroblast subsets in healthy and injured tissues,, but …

Many lung diseases result from a failure of efficient regeneration of damaged alveolar
epithelial cells (AECs) after lung injury. During regeneration, AEC2s proliferate to replace …

Inflammatory responses are known to facilitate tissue recovery following injury. However, the
precise mechanisms that enhance lung alveolar regeneration remain unclear. Here, using …

Broadly, tissue regeneration is achieved in two ways: by proliferation of common
differentiated cells and/or by deployment of specialized stem/progenitor cells. Which of these …