Mitochondria are an essential source of ATP for cellular function, but when damaged,
mitochondria generate a plethora of stress signals, which lead to cellular dysfunction and …

Fasting in vivo and nutrient deprivation in vitro enhance sequestration of mitochondria and
other organelles by autophagy for recycling of essential nutrients. Here our goal was to use …

Autophagy is a catabolic process involving vacuolar sequestration of intracellular
components and their targeting to lysosomes for degradation, thus supporting nutrient …

Recent reports indicated that mitophagy protects against alcohol-induced liver injury, which
helps remove damaged mitochondria to reduce the accumulation of reactive oxygen species …

Macroautophagy/autophagy is a degradative process essential for various cellular
processes. We previously demonstrated that autophagy-deficiency causes myoblast …

Mitochondrial oxidative phosphorylation (OXPHOS) generates ATP, but OXPHOS also
supports biosynthesis during proliferation. In contrast, the role of OXPHOS during …

Mitochondrial integrity is critical for maintaining proper cellular functions. A key aspect of
regulating mitochondrial homeostasis is removing damaged mitochondria through …

During alcohol consumption, the esophageal mucosa is directly exposed to high
concentrations of ethanol (EtOH). We therefore investigated the response of normal human …

Mitochondria are the main cellular energy powerhouses and supply most of the energy in
the form of ATP to fuel essential neuronal functions through oxidative phosphorylation …

Ethanol-induced hepatic lipophagy plays an important cytoprotective role against liver injury,
but its mechanism is not fully determined. In the present study, ethanol-induced lipophagy …