Excessive alcohol consumption induces intestinal dysbiosis of the gut microbiome and
reduces gut epithelial integrity. This often leads to portal circulation–mediated translocation …

Our latest publication on the inhibition of Alzheimer disease (AD) through mitophagy
consolidates the 'defective mitophagy hypothesis of AD etiology'. Dementia (majorly AD) …

Mitophagy is a selective autophagic process, essential for cellular homeostasis, that
eliminates dysfunctional mitochondria. Activated by inner membrane depolarization, it plays …

Mitophagy formed the basis of the original description of autophagy by Christian de Duve
when he demonstrated that GCG (glucagon) induced macroautophagic/autophagic turnover …

Mitochondria are the powerhouses of cells and produce cellular energy in the form of ATP.
Mitochondrial dysfunction contributes to biological aging and a wide variety of disorders …

In cultured cells, not many mitochondria are degraded by mitophagy induced by
physiological cellular stress. We observed mitophagy in HeLa cells using a method that …

Background and aim Mitophagy is a lysosomal degradation pathway that selectively
removes damaged, aged and dysfunctional mitochondria. Recent advances in …

Autophagy evolved as a mechanism to sustain cellular homeostasis during instances of
nutrient deprivation. Mounting evidence has also clarified that under basal and stress …

Mitophagy is a process of selective removal of damaged or unnecessary mitochondria using
autophagy machinery. Close links have been found between defective mitophagy and …

We are investigating the changes in hepatic lipid catabolism that contribute to alcohol-
induced fatty liver. Following chronic ethanol (EtOH) exposure, abstinence from alcohol …