Mitochondrial dysfunction has severe cellular consequences and is linked with
neurodegenerative diseases and aging. Maintaining a healthy population of mitochondria is …

ABSTRACT ATM (ataxia telangiectasia mutated) protein is found associated with multiple
organelles including synaptic vesicles, endosomes and lysosomes, often in cooperation with …

Pancreatic cancer tends to be highly resistant to current therapy and remains one of the
great challenges in biomedicine with very low 5-year survival rates. Here, we report that …

Background Autophagy (macroautophagy), a cellular process of “self-eating”, segregates
damaged/aged organelles into vesicles, fuses with lysosomes, and enables recycling of the …

Mitochondria are highly dynamic organelles, with a morphology ranging from small roundish
elements to large interconnected networks. This fine architecture has a significant impact on …

Macroautophagy (henceforth autophagy) an evolutionary conserved intracellular pathway,
involves lysosomal degradation of damaged and superfluous cytosolic contents to maintain …

Reactive oxygen and nitrogen species change cellular responses through diverse
mechanisms that are now being defined. At low levels, they are signalling molecules, and at …

Mitochondrial dynamics and mitophagy are thought to be important events for the quality
control of mitochondria and mitochondria‐associated diseases. To identify novel mitophagy …

Autophagy is an important lysosome-mediated intracellular degradation pathway required
for tissue homeostasis. Dysregulation of liver autophagy is closely associated with different …

The pathogenesis of non-alcoholic steatohepatitis (NASH) is poorly understood. Here,
relationships between mitochondrial depolarization (mtDepo) and mitochondrial …