Malaria parasite transmission to mosquitoes relies on the uptake of sexual stage parasites
during a blood meal and subsequent formation of oocysts on the mosquito midgut wall …

Transmission-blocking vaccines are based on eliciting antibody responses in the vertebrate
host that disrupt parasite development in the mosquito vector and prevent malaria …

Malaria transmission-blocking vaccines (TBVs) aim to induce antibodies that interrupt
malaria parasite development in the mosquito, thereby blocking onward transmission, and …

In the progression of the life cycle of Plasmodium falciparum, a small proportion of asexual
parasites differentiate into male or female sexual forms called gametocytes. Just like their …

Currently, there is no animal model for Plasmodium falciparum challenge to evaluate
malaria transmission-blocking vaccines based on the well-established Pfs25 target antigen …

Gametocytes are the specialized form of Plasmodium parasites that are responsible for
human-to-mosquito transmission of malaria. Transmission of gametocytes is highly effective …

Introduction: The development of effective vaccines remains a major health priority to
combat the global burden of malaria, a life-threatening disease caused by Plasmodium …

The idea of malaria transmission-blocking vaccines (TBVs) surfaced more than two decades
ago. Since then, the research paradigm focused on developing TBVs that target surface …

Transmission-blocking vaccines have the potential to be key contributors to malaria
elimination. Such vaccines elicit antibodies that inhibit parasites during their development in …

Malaria transmission-blocking vaccines (TBVs) aim to induce antibodies that block
Plasmodium parasite development in the mosquito midgut, thus preventing mosquitoes from …