430 FRASER d-isomers and N-allylnormorphine, an antagonist for opiate drugs, also in
hibits N-demethylation of these compounds (22). Treatment of physical dependence on …

Drug addiction is a condition in which an individual has lost the power of self-control with
reference to a drug and abuses the drug to such an extent that the individual, society, or both …

Excerpt Drug addiction is a condition in which an individual has become sufficiently subject
to an effect of a drug that he can no longer exert adequate self-control with regard to its …

The effects of large doses of morphine in nontolerant and tolerant rats as well as the effects
of abruptly withdrawing morphine in rats experimentally addicted to large doses of morphine …

Morphine is considered the best pain relieving drug which the clinician has at his disposal,
yet there are elements of tolerance, addiction and gastrointestinal disadvantages to its use. It …

CQUIRED tolerance is known to occur to A a wide variety of chemical substances, of which
morphine and its congeners are but classic examples. In the limited space available here …

Restlessness and vomiting. which maintains a hospital in Lexington, Kentucky.
Himmelsbach, Isbell, Wikler and their coworkers are especially associated with the …

The discovery of any potent analgesic drug always raises the question of the danger of
addiction to the drug. The idea that the drugs of the phenanthrene series (morphine and …

—-I■ I■ I ii■ m■..................—r 1• UNIVERSITY MICROFILMS, ANN ARBOR, MICH. $• LC
Card no. Mie 58-900•• _ _ _ _ _ _ _ _ _; _ _ _ _ _ _ _ _ _-—I DENEAU, Gerald Antoine. AN …

Research Division, U. 8. Public Health Service Hospital, Lexington, Kent ucky assessing the
addiction liability of new drugs, attention must be I" paid to all three of the qualities which …