Distinct metabolic pathways trigger adipocyte fat accumulation induced by high-carbohydrate and high-fat diets

AVM Ferreira, Z Menezes-Garcia, JB Viana, ÉG Mário… - Nutrition, 2014 - Elsevier
Objective Several metabolic pathways may be associated with obesity development and
may be differentially modulated by dietary constituents. The aim of this study was to access …

Isocaloric intake of a high-fat diet modifies adiposity and lipid handling in a sex dependent manner in rats

ME Estrany, AM Proenza, I Lladó, M Gianotti - Lipids in health and disease, 2011 - Springer
Background High-fat (HF) diet feeding usually leads to hyperphagia and body weight gain,
but macronutrient proportions in the diet can modulate energy intake and fat deposition. The …

Nature of fatty acids in high fat diets differentially delineates obesity-linked metabolic syndrome components in male and female C57BL/6J mice

S El Akoum, V Lamontagne, I Cloutier… - Diabetology & metabolic …, 2011 - Springer
Background Adverse effects of high-fat diets (HFD) on metabolic homeostasis are linked to
adipose tissue dysfunction. The goal of this study was to examine the effect of the HFD …

Causes and mechanisms of adipocyte enlargement and adipose expansion

F Haczeyni, KS Bell‐Anderson, GC Farrell - Obesity reviews, 2018 - Wiley Online Library
Adipose tissue plays a significant role in whole body energy homeostasis. Obesity‐
associated diabetes, fatty liver and metabolic syndrome are closely linked to adipose stress …

Mechanisms preserving insulin action during high dietary fat intake

AM Lundsgaard, JB Holm, KA Sjøberg… - Cell Metabolism, 2019 - cell.com
Prolonged intervention studies investigating molecular metabolism are necessary for a
deeper understanding of dietary effects on health. Here we provide mechanistic information …

Dietary fat intake promotes the development of hepatic steatosis independently from excess caloric consumption in a murine model

VE De Meijer, HD Le, JA Meisel, MRA Sharif, A Pan… - Metabolism, 2010 - Elsevier
Nonalcoholic fatty liver disease results from overconsumption and is a significant and
increasing cause of liver failure. The type of diet that is conducive to the development of this …

Altered expression of transcription factors and genes regulating lipogenesis in liver and adipose tissue of mice with high fat diet-induced obesity and nonalcoholic fatty …

K Morgan, A Uyuni, G Nandgiri, L Mao… - European journal of …, 2008 - journals.lww.com
Objective To determine whether expression of transcription factors and lipogenic enzymes is
altered in liver and adipose tissue of mice with obesity, insulin resistance, and nonalcoholic …

Comparison of the expression and activity of the lipogenic pathway in human and rat adipose tissue

D Letexier, C Pinteur, V Large, V Fréring… - Journal of lipid …, 2003 - ASBMB
Lipogenesis is considered less active in human than in rat adipose tissue. This could be
explained by different nutritional conditions, namely high-carbohydrate (HCHO) diet in rats …

Metabolic differences between subcutaneous and visceral adipocytes differentiated with an excess of saturated and monounsaturated fatty acids

M Małodobra-Mazur, A Cierzniak, D Pawełka… - Genes, 2020 - mdpi.com
Obesity is a major health problem in highly industrialized countries. High-fat diet (HFD) is
one of the most common causes of obesity and obesity-related disorders. There are …

Gene expression modulation of lipid and central energetic metabolism related genes by high-fat diet intake in the main homeostatic tissues

B Reynés, M Palou, A Palou - Food & function, 2017 - pubs.rsc.org
It is generally assumed that high-fat (HF) diets induce characteristic gene expression
regulation, which may cause metabolic alterations associated with an increased risk of …