Hepatic lipid accumulation is an initiation factor in fatty liver disease, and promoting a
reduction in hepatic lipid accumulation is an important treatment strategy. DEAD box RNA …

During the last decade, the understanding of the biological functions of cholesterol
biosynthesis intermediates has changed significantly. Particularly, the enzyme sterol …

Inhibition of 11β-HSD1 is viewed as a potential target for the treatment of obesity and other
elements of the metabolic syndrome. We report here the optimization of a carboxylic acid …

The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) converts cortisone to
the active glucocorticoid cortisol, thereby acting as a cellular switch to mediate …

11β-Hydroxysteroid dehydrogenase (11β-HSD) enzymes catalyze the conversion of
biologically inactive 11-ketosteroids into their active 11β-hydroxy derivatives and vice versa …

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide and macrophage polarization plays an important role in its pathogenesis …

Objective Fibrotic organ responses have recently been identified as long-term complications
in diabetes. Indeed, insulin resistance and aberrant hepatic lipid accumulation represent …

Background 17β-hydroxysteroid dehydrogenase type 10 (HSD10) has been shown to play a
protective role in cells undergoing stress. Upregulation of HSD10 under nutrient-limiting …

OBJECTIVE: The authors performed a systematic review and meta-analysis to investigate
the role of rs72613567 within hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13) in …

Abstract Background & Aims The loss‐of‐function rs72613567 T> TA‐variant in the 17β‐
hydroxysteroid dehydrogenase 13 (HSD17B13) gene might protect from alcoholic and non …