[HTML][HTML] The human urine metabolome

S Bouatra, F Aziat, R Mandal, AC Guo, MR Wilson… - PloS one, 2013 - journals.plos.org
Urine has long been a “favored” biofluid among metabolomics researchers. It is sterile, easy-
to-obtain in large volumes, largely free from interfering proteins or lipids and chemically …

Challenges in metabolomics-based tests, biomarkers revealed by metabolomic analysis, and the promise of the application of metabolomics in precision medicine

A Di Minno, M Gelzo, M Caterino, M Costanzo… - International Journal of …, 2022 - mdpi.com
Metabolomics helps identify metabolites to characterize/refine perturbations of biological
pathways in living organisms. Pre-analytical, analytical, and post-analytical limitations that …

“Notame”: workflow for non-targeted LC–MS metabolic profiling

A Klåvus, M Kokla, S Noerman, VM Koistinen… - Metabolites, 2020 - mdpi.com
Metabolomics analysis generates vast arrays of data, necessitating comprehensive
workflows involving expertise in analytics, biochemistry and bioinformatics in order to …

NMR metabolomics of human blood and urine in disease research

IF Duarte, SO Diaz, AM Gil - Journal of Pharmaceutical and Biomedical …, 2014 - Elsevier
This paper reviews the main applications of NMR metabolomics of blood and urine in
disease research, over the last 5 years. The broad range of disease types addressed attests …

Metabolomics: an emerging but powerful tool for precision medicine

CB Clish - Molecular Case Studies, 2015 - molecularcasestudies.cshlp.org
Metabolomics, which is defined as the comprehensive analysis of metabolites in a biological
specimen, is an emerging technology that holds promise to inform the practice of precision …

Recent advances in NMR-based metabolomics

GA Nagana Gowda, D Raftery - Analytical Chemistry, 2017 - ACS Publications
NMR spectroscopy, one of the two major analytical platforms utilized in the metabolomics
field, has witnessed a large number of advances in fundamental studies, methods …

Interlaboratory reproducibility of a targeted metabolomics platform for analysis of human serum and plasma

AP Siskos, P Jain, W Römisch-Margl… - Analytical …, 2017 - ACS Publications
A critical question facing the field of metabolomics is whether data obtained from different
centers can be effectively compared and combined. An important aspect of this is the …

Exploring disease through metabolomics

N Vinayavekhin, EA Homan… - ACS chemical biology, 2010 - ACS Publications
Metabolomics approaches provide an analysis of changing metabolite levels in biological
samples. In the past decade, technical advances have spurred the application of …

Large-scale targeted metabolomics method for metabolite profiling of human samples

G Cao, Z Song, Y Hong, Z Yang, Y Song, Z Chen… - Analytica Chimica …, 2020 - Elsevier
Targeted metabolomics has significant advantages for quantification but suffers from
reduced metabolite coverage. In this study, we developed a large-scale targeted …

Recent and potential developments of biofluid analyses in metabolomics

A Zhang, H Sun, P Wang, Y Han, X Wang - Journal of proteomics, 2012 - Elsevier
Metabolomics, one of the 'omic'sciences in systems biology, is the global assessment and
validation of endogenous small-molecule metabolites within a biologic system. Analysis of …