Importance Current evidence is conflicting for associations of extended-infusion β-lactam (EI-
BL) therapy with clinical outcomes. Objective To investigate the association of EI-BL therapy …

Background Optimal β-lactam dosing for the treatment of Gram-negative bacteria
bloodstream infections (GNB-BSIs) remains a debated issue. Herein, the efficacy and safety …

Objectives Increasing antimicrobial resistance rates limit empirical antimicrobial treatment
options for Gram-negative bloodstream infections (GN-BSI). However, antimicrobial …

Objectives To evaluate the association between early and cumulative beta-lactam
pharmacokinetic/pharmacodynamic (PK/PD) parameters and therapy outcomes in …

Background Resistance to all first-line antibiotics necessitates the use of less effective or
more toxic “reserve” agents. Gram-negative bloodstream infections (GNBSIs) harboring such …

Objectives In this study, we evaluated the clinical outcomes associated with the use of highly
bioavailable oral antibiotics (fluoroquinolones and trimethoprim-sulfamethoxazole) …

Objectives The potential benefit from appropriate empirical antimicrobial therapy in patients
with favourable prognosis at initial presentation with Gram-negative bloodstream infection …

Objective Short-course aminoglycosides as adjunctive empirical therapy to β-lactams in
patients with a clinical suspicion of sepsis are used to broaden antibiotic susceptibility …

Importance Management of gram-negative bloodstream infections (GN-BSIs) with oral
antibiotics is highly variable. Objective To examine the transition from intravenous (IV) to oral …

The utility of empirical combination antimicrobial therapy for Gram-negative bloodstream
infection (BSI) remains unclear. This retrospective, quasi-experimental matched cohort study …