IL-22 is a Th17/Th22 cytokine that is increased in asthma. However, recent animal studies
showed controversial findings in the effects of IL-22 in allergic asthma. To determine the role …

Rationale: IL-22 has both proinflammatory and antiinflammatory properties. Its role in
allergic lung inflammation has not been explored. Objectives: To investigate the expression …

Allergic inflammation in the airway is generally considered a Th2-type immune response.
However, Th17-type immune responses also play important roles in this process, especially …

Asthma is a chronic inflammatory disease of the airways that is characterized by eosinophilic
inflammation, mucus hypersecretion and airway remodeling that leads to airway obstruction …

Interleukin (IL)-22 is an effector cytokine, which acts primarily on epithelial cells in the skin,
gut, liver and lung. Both pro-and anti-inflammatory properties have been reported for IL-22 …

BACKGROUND: IL-22 functions as both a proinflammatory cytokine and an anti-
inflammatory cytokine in various inflammations, depending on the cellular and cytokine …

Background Allergic asthma is a chronic airway inflammatory disease with a number of
cytokines participating in its pathogenesis and progress. Interleukin (IL)-22, which is derived …

Background Serum IL-22 levels are increased in patients with atopic dermatitis, which
commonly precedes asthma in the atopic march. Epicutaneous sensitization in mice results …

Allergic asthma occurs as a consequence of inappropriate immunologic inflammation to
allergens and characterized by Th2 adaptive immune response. Recent studies indicated …

IL‐23‐and IL‐17A‐producing CD4+ T cell (Th17 cell) axis plays a crucial role in the
development of chronic inflammatory diseases. In addition, it has been demonstrated that …