In this paper, the genetic aspects of the phenotypic alterations observed in cells after
malignant transformation are discussed. A number of discrete and stable phenotypic …

Seven different transformation stigmata of the transformed CHO cell line, including
morphological characteristics, growth behavior, cell membrane biochemical properties, and …

Although there was a publication" Chromo-somes and Cancer"(J. Wiley and Sons) in 1974,
the editor, James German pointedout in his Introduction that most of the investigations …

A not yet understood phenomenon in carcinogenesis is presented by the enormous species-
specific and age-specific differences in cellular susceptibility to malignant transformation …

A unifying concept that appears to provide an understanding of cancer as a fundamental
scientific problem is presented. This concept, which was initially developed on the basis of …

Chinese hamster embryo fibroblast cell line CHEF/18 is stably diploid, anchorage-
dependent, has a high serum requirement, and does not form tumors in nude mice. The …

The initiating event responsible for the conversion of normal to neoplastic cells has engaged
the attention of many investigators, but numerous exceptions have been encountered …

This discussion is concerned with the multiplicity of factors that influence the initiation of
neoplasia and its subsequent course. Factors that are not strictly “carcinogenic” may …

The concept that neoplasia results from an accumulation of somatic mutations in the tumour
lineage is heuristically extremely useful. Strong support for this hypothesis has been …

Publisher Summary This chapter outlines the conditions of selection of variant cells and
discusses the resulting phenotypic modifications permitting the survival and growth of the …