Background: Alzheimer's disease (AD) is a multifactorial disease, implying that multi-target
treatments may be necessary to effectively cure AD. Tetrahydrobiopterin (BH4) is an …

Tetrahydrobiopterin (BH4) is synthesized by the combined action of three metabolic
pathways, namely de novo synthesis, recycling, and salvage pathways. The best-known …

Diets containing a high proportion of fat with respect to protein plus carbohydrates are
capable of inducing ketone body production in the liver, which provides an energetic …

4-phenylbutyrate (PBA) is a histone deacetylase (HDAC) inhibitor whose efficacy in the
Tg2576 mouse model of Alzheimer´ s disease (AD) is correlated with decreased tau …

Reduction of glucose metabolism in brain is one of the main features of Alzheimer's disease.
Thiamine (vitamin B1)-dependent processes are critical in glucose metabolism and have …

Background: Accumulation of amyloid β (Aβ) peptide, inflammation, and oxidative stress
contribute to Alzheimer's disease (AD) and trigger complex pathogenesis. The ketone body …

Alzheimer's disease (AD) is characterized by early impairments in memory and progressive
neurodegeneration. Disruption of synaptic plasticity processes that underlie learning and …

A double blind, placebo-controlled phase II study revealed that the antihistamine,
Dimebon®(dimebolin, latrepirdine) improved cognition in Alzheimer disease (AD) patients …

In an aging society, Alzheimer's disease (AD) exerts an increasingly serious health and
economic burden. Current treatments provide inadequate symptomatic relief as several …

Background Alzheimer's disease (AD) is characterized by a polyetiological origin. Despite
the global burden of AD and the advances made in AD drug research and development, the …