Accumulating evidences demonstrated that epigenetic modification of the expression of
specific genes contributed to the pathogenesis of neurological disorders with dementia …

Downregulation of brain-derived neurotrophic factor (BDNF) in the cortex occurs early in the
progression of Alzheimer's disease (AD). Since BDNF plays a critical role in neuronal …

Alzheimer's disease (AD) is a senile dementia characterized by amyloid plaques,
neurofibrillary tangles, and synaptic and cell loss. The “amyloid cascade” hypothesis …

Brain-derived neurotrophic factor (BDNF) has a neurotrophic support on neuron of central
nervous system (CNS) and is a key molecule in the maintenance of synaptic plasticity and …

Alzheimer's disease (AD) is a widespread chronic neurodegenerative pathology
characterized by synaptic dysfunction, partial neuronal death, cognitive decline and memory …

The β-amyloid protein (Aβ) is the major component of senile plaques found in the brain in
Alzheimer's disease (AD). Its neurotoxic properties in vivo, however, are not well defined …

An emerging body of data suggests that the early onset of Alzheimer's disease (AD) is
associated with decreased brain-derived neurotrophic factor (BDNF). Because BDNF plays …

Reduced expression of brain-derived neurotrophic factor (BDNF) has a crucial role in the
pathogenesis of Alzheimer's disease (AD), which is characterized with the formation of …

Our previous studies demonstrate that a non-cholinesterase inhibitor (AChEI) compound
catalpol, purified from a traditional Chinese medicinal herb Rehmannia glutinosa, could …

Brain-derived neurotrophic factor (BDNF) is important in the development and maintenance
of neurons and their plasticity. Hippocampal BDNF has been implicated in Alzheimer's …