Early BDNF treatment ameliorates cell loss in the entorhinal cortex of APP transgenic mice
AH Nagahara, M Mateling, I Kovacs… - Journal of …, 2013 - Soc Neuroscience
Brain-derived neurotrophic factor (BDNF) improves molecular, cellular, and behavioral
measures of neural dysfunction in genetic models of Alzheimer's disease (;). However …
measures of neural dysfunction in genetic models of Alzheimer's disease (;). However …
Decreased levels of BDNF protein in Alzheimer temporal cortex are independent of BDNF polymorphisms
J Lee, H Fukumoto, J Orne, J Klucken, S Raju… - Experimental …, 2005 - Elsevier
Levels of brain-derived neurotrophic factor (BDNF) are reduced in specific brain regions in
Alzheimer's disease (AD) and BDNF gene polymorphisms have been suggested to …
Alzheimer's disease (AD) and BDNF gene polymorphisms have been suggested to …
[图书][B] Neurotrophic factors and Alzheimer's disease: are we focusing on the wrong molecule?
M Fahnestock, D Garzon, RMD Holsinger, B Michalski - 2002 - Springer
Brain derived neurotrophic factor (BDNF) promotes cholinergic neuron function and survival.
In Alzheimer's disease, BDNF mRNA and protein are decreased in basal forebrain …
In Alzheimer's disease, BDNF mRNA and protein are decreased in basal forebrain …
Gene therapy delivers an alternative approach to Alzheimer's disease
E Kennington - Nature Reviews Drug Discovery, 2009 - nature.com
The main focus of current drug development efforts for Alzheimer's disease is targeting the
amyloid-β (Aβ) brain plaques that are characteristic of the disease. However, there have …
amyloid-β (Aβ) brain plaques that are characteristic of the disease. However, there have …
Amyloid β up‐regulates brain‐derived neurotrophic factor production from astrocytes: Rescue from amyloid β‐related neuritic degeneration
N Kimura, M Takahashi, T Tashiro… - Journal of neuroscience …, 2006 - Wiley Online Library
Astrocytes, the most abundant type of glia in the brain, are considered to play a key role in
Alzheimer's disease (AD) pathologies. In a cell culture study, we have previously shown that …
Alzheimer's disease (AD) pathologies. In a cell culture study, we have previously shown that …
[HTML][HTML] Dexmedetomidine attenuates the toxicity of β‑amyloid on neurons and astrocytes by increasing BDNF production under the regulation of HDAC2 and HDAC5
Y Wang, A Jia, W Ma - Molecular Medicine Reports, 2019 - spandidos-publications.com
Cytotoxicity of β-Amyloid (Aβ) is a major contributor to the pathogenesis of Alzheimer's
disease. Dexmedetomidine (Dex) has been revealed to have multiple neuroprotective …
disease. Dexmedetomidine (Dex) has been revealed to have multiple neuroprotective …
1H-MRS assessment of the therapeutic effect of bilateral intraventricular BDNF infusion into APP/PS1 double transgenic mice
W Zhang, P Wang, M Li, G Wang, P Li… - Journal of Molecular …, 2013 - Springer
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by extracellular
accumulation of amyloid deposits. Brain-derived neurotrophic factor (BDNF) is a …
accumulation of amyloid deposits. Brain-derived neurotrophic factor (BDNF) is a …
Dual response of BDNF to sublethal concentrations of β-amyloid peptides in cultured cortical neurons
E Aliaga, M Silhol, N Bonneau, T Maurice… - Neurobiology of …, 2010 - Elsevier
Beta-amyloid (Aβ) deposition is one important pathological hallmark in Alzheimer's disease
(AD). However, low levels of Aβ may modify critical endogenous protection systems before …
(AD). However, low levels of Aβ may modify critical endogenous protection systems before …
Brain-derived neurotrophic factor prevents against amyloid beta protein-induced impairment of hippocampal in vivo long-term potentiation in rats
QS Li, W Yang, YF Pan, J Min, Z Zhang… - Zhongguo Ying Yong …, 2012 - europepmc.org
Objective To explore the effects of brain-derived neurotrophic factor (BDNF) pretreatment on
beta amyloid protein (Abeta) induced impairment of in vivo hippocampal long-term …
beta amyloid protein (Abeta) induced impairment of in vivo hippocampal long-term …
Correlation between hippocampal BDNF mRNA expression and memory performance in senescent rats
MJM Schaaf, JO Workel, HM Lesscher, E Vreugdenhil… - Brain research, 2001 - Elsevier
Brain-derived neurotrophic factor (BDNF) has been suggested to be involved in memory
processes. In the present study, the association between memory impairment at senescence …
processes. In the present study, the association between memory impairment at senescence …