Correlations between neuronal loss, decrease of memory, and decrease expression of brain-derived neurotrophic factor in the gerbil hippocampus during normal …
IK Hwang, KY Yoo, BK Jung, JH Cho, DH Kim… - Experimental …, 2006 - Elsevier
It is known that the hippocampus has vital functions in learning and memory, behavioral
regulation, and activity-dependent synaptic plasticity, and that the hippocampus contains …
regulation, and activity-dependent synaptic plasticity, and that the hippocampus contains …
Neurotrophins and other growth factors in the pathogenesis of Alzheimer's disease
T Numakawa, R Kajihara - Life, 2023 - mdpi.com
The involvement of the changed expression/function of neurotrophic factors in the
pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD), has been …
pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD), has been …
Brain-derived neurotrophic factor signaling in the pathophysiology of Alzheimer's disease: Beneficial effects of flavonoids for neuroprotection
T Numakawa, H Odaka - International Journal of Molecular Sciences, 2021 - mdpi.com
The function of the brain-derived neurotrophic factor (BDNF) via activation through its high-
affinity receptor Tropomyosin receptor kinase B (TrkB) has a pivotal role in cell …
affinity receptor Tropomyosin receptor kinase B (TrkB) has a pivotal role in cell …
Signaling mechanisms mediating BDNF modulation of memory formation in vivo in the hippocampus
M Alonso, MRM Vianna, I Izquierdo… - Cellular and molecular …, 2002 - Springer
Given that brain-derived neutrophic factor (BDNF) modulates both short-term synaptic
function and activity-dependent synaptic plasticity in the adult hippocampus, here we …
function and activity-dependent synaptic plasticity in the adult hippocampus, here we …
PGC-1α or FNDC5 Is Involved in Modulating the Effects of Aβ1−42 Oligomers on Suppressing the Expression of BDNF, a Beneficial Factor for Inhibiting Neuronal …
DY Xia, X Huang, CF Bi, LL Mao, LJ Peng… - Frontiers in aging …, 2017 - frontiersin.org
Alzheimer's disease (AD) is generally defined as the aberrant production of β-amyloid
protein (Aβ) and hyperphosphorylated tau protein, which are deposited in β-amyloid …
protein (Aβ) and hyperphosphorylated tau protein, which are deposited in β-amyloid …
Developmental and degenerative modulation of brain-derived neurotrophic factor transcript variants in the mouse hippocampus
J Kim, M Yang, J Kim, L Song, S Lee, Y Son… - International Journal of …, 2014 - Elsevier
Brain-derived neurotrophic factor (BDNF) is regarded as an important factor for
neurogenesis, synaptic plasticity, and neuronal network organization in brain circuits …
neurogenesis, synaptic plasticity, and neuronal network organization in brain circuits …
The aging hippocampus: interactions between exercise, depression, and BDNF
KI Erickson, DL Miller, KA Roecklein - The Neuroscientist, 2012 - journals.sagepub.com
Late adulthood is associated with increased hippocampal atrophy and dysfunction. Although
there are multiple paths by which hippocampal deterioration occurs in late life, the authors …
there are multiple paths by which hippocampal deterioration occurs in late life, the authors …
BDNF prevents amyloid-dependent impairment of LTP in the entorhinal cortex by attenuating p38 MAPK phosphorylation
C Criscuolo, C Fabiani, C Bonadonna, N Origlia… - Neurobiology of …, 2015 - Elsevier
The oligomeric form of the amyloid peptide Aβ 1–42 is capable of perturbing synaptic
plasticity in different brain areas. Here, we evaluated the protective role of brain-derived …
plasticity in different brain areas. Here, we evaluated the protective role of brain-derived …
Conditional depletion of hippocampal brain-derived neurotrophic factor exacerbates neuropathology in a mouse model of Alzheimer's disease
Damage occurring to noradrenergic neurons in the locus coeruleus (LC) contributes to the
evolution of neuroinflammation and neurodegeneration in a variety of conditions and …
evolution of neuroinflammation and neurodegeneration in a variety of conditions and …
Exogenous brain-derived neurotrophic factor attenuates cognitive impairment induced by okadaic acid in a rat model of Alzheimer's disease
AH Xu, Y Yang, YX Sun, CD Zhang - Neural Regeneration …, 2018 - journals.lww.com
Decreased expression of brain-derived neurotrophic factor (BDNF) plays an important role
in the pathogenesis of Alzheimer's disease, and a typical pathological change in Alzheimer's …
in the pathogenesis of Alzheimer's disease, and a typical pathological change in Alzheimer's …