Emphasizing roles of BDNF promoters and inducers in Alzheimer's disease for improving impaired cognition and memory

M Banerjee, RR Shenoy - Journal of Basic and Clinical Physiology …, 2023 - degruyter.com
Brain-derived neurotrophic factor (BDNF) is a crucial neurotrophic factor adding to neurons'
development and endurance. The amount of BDNF present in the brain determines …

Effect of the brain‐derived neurotrophic factor and the apolipoprotein E polymorphisms on disease progression in preclinical Alzheimer's disease

R Hashimoto, Y Hirata, T Asada… - Genes, Brain and …, 2009 - Wiley Online Library
Genetic factors, such as apolipoprotein E (ApoE) polymorphisms, are thought to play an
important role in the etiology of Alzheimer's disease (AD). Recent association studies have …

Transduced PTD-BDNF fusion protein protects against beta amyloid peptide-induced learning and memory deficits in mice

JP Zhou, ZG Feng, BL Yuan, SZ Yu, Q Li, HY Qu… - Brain research, 2008 - Elsevier
Brain-derived neurotrophic factor (BDNF) promotes the survival and differentiation of
hippocampal, cortical, and basal forebrain cholinergic neurons. However, the efficacy of …

The role of CREB and BDNF in neurobiology and treatment of Alzheimer's disease

M Amidfar, J de Oliveira, E Kucharska, J Budni, YK Kim - Life sciences, 2020 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia worldwide. β-amyloid
peptide (Aβ) is currently assumed to be the main cause of synaptic dysfunction and cognitive …

[HTML][HTML] The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function

MF Egan, M Kojima, JH Callicott, TE Goldberg… - Cell, 2003 - cell.com
Brain-derived neurotrophic factor (BDNF) modulates hippocampal plasticity and
hippocampal-dependent memory in cell models and in animals. We examined the effects of …

Amyloid‐beta induced changes in vesicular transport of BDNF in hippocampal neurons

B Seifert, R Eckenstaler, R Rönicke, J Leschik… - Neural …, 2016 - Wiley Online Library
The neurotrophin brain derived neurotrophic factor (BDNF) is an important growth factor in
the CNS. Deficits in transport of this secretory protein could underlie neurodegenerative …

A novel polymorphism of the brain-derived neurotrophic factor (BDNF) gene associated with late-onset Alzheimer's disease

H Kunugi, A Ueki, M Otsuka, K Isse, H Hirasawa… - Molecular …, 2001 - nature.com
Several lines of evidence have suggested altered functions of the brain-derived
neurotrophic factor (BDNF) in the pathogenesis of neurodegenerative diseases including …

Difference in methylation and expression of brain-derived neurotrophic factor in Alzheimer's disease and mild cognitive impairment

K Kouter, M Nikolac Perkovic, G Nedic Erjavec, T Milos… - Biomedicines, 2023 - mdpi.com
Due to the increasing number of progressive dementias in the population, numerous studies
are being conducted that seek to determine risk factors, biomarkers and pathological …

Variations in the BDNF Gene in Autopsy-Confirmed Alzheimer's Disease and Dementia with Lewy Bodies in Japan

H Akatsu, HD Yamagata, J Kawamata… - Dementia and geriatric …, 2006 - karger.com
Abstract Background/Aim: Brain-derived neurotrophic factor (BDNF) is associated with the
hippocampus and the nigrostriatal dopaminergic function. Data showing that its level was …

Amyloid β serves as an NGF‐like neurotrophic factor or acts as a NGF antagonist depending on its concentration

MÁ Arevalo, PM Roldan, PJ Chacón… - Journal of …, 2009 - Wiley Online Library
In the nervous system, both the shape and connectivity of neurons are strongly influenced by
soluble, extracellular factors. Indeed, we recently demonstrated that after binding to …