It has been well documented that neurotrophins, including brain-derived neurotrophic factor
(BDNF), are severely affected in Alzheimer's disease (AD), but their administration faces a …

Nerve growth factor (NGF) is an important nerve cell growth regulatory factor and has an
indispensable role in the development, survival and regeneration of the cholinergic basal …

Alzheimer's disease (AD) is the most common neurodegenerative disease influenced by
genetic and environmental factors. Brain-derived neurotrophic factor (BDNF) plays an …

Scope Brain‐derived neurotrophic factor (BDNF) is a neurotrophin that supports the survival
of existing neurons and encourages the growth and differentiation of new neurons and …

The accumulation of β-amyloid (Aβ) is one of the etiological factors in Alzheimer's disease
(AD). It has been assumed that the underlying mechanism involves a critical role of Aβ …

Soluble oligomeric forms of amyloid beta (Aβ) play an important role in causing the cognitive
deficits in Alzheimer's disease (AD) by targeting and disrupting synaptic pathways. Thus, the …

Neurotrophins play a crucial role in mediating neuronal survival and synaptic plasticity. A
lack of trophic factor support in the peripheral nervous system (PNS) is associated with a …

Increasing evidence suggests that synaptic dysfunction is a key pathophysiological hallmark
in neurodegenerative disorders, including Alzheimer's disease. Understanding the role of …

Degeneration of basal forebrain cholinergic neurons (BFCNs) precedes hippocampal
degeneration and pathological amyloid-beta (Aβ) accumulation, and underpins the …

Introduction Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the
most common cause of dementia among the elderly population. AD is accompanied with the …