Stromal cells can contribute oncogenic signals

TD Tlsty - Seminars in cancer biology, 2001 - Elsevier
The majority of studies of neoplastic transformation have focused attention on events that
occur within transformed cells. These cell autonomous events result in the disruption of …

Know thy neighbor: stromal cells can contribute oncogenic signals

TD Tlsty, PW Hein - Current opinion in genetics & development, 2001 - Elsevier
Although the stroma within carcinogenic lesions is known to be supportive and responsive to
tumors, new data increasingly show that the stroma also has a more active, oncogenic role …

Watch thy neighbor: cancer is a communal affair

VM Weaver, P Gilbert - Journal of cell science, 2004 - journals.biologists.com
Malignant transformation of an epithelium occurs within the context of a dynamically
evolving tissue stroma that is composed of multiple cell types surrounded by an extracellular …

Tumor microenvironment: the role of the tumor stroma in cancer

H Li, X Fan, JM Houghton - Journal of cellular biochemistry, 2007 - Wiley Online Library
The tumor microenvironment, composed of non‐cancer cells and their stroma, has become
recognized as a major factor influencing the growth of cancer. The microenvironment has …

New insights into the role of extracellular matrix during tumor onset and progression

SM Pupa, S Ménard, S Forti… - Journal of cellular …, 2002 - Wiley Online Library
Recently, a view of the tumor as a functional tissue interconnected with the
microenvironment has recently been described. For many years, the stroma has been …

Tumor–stroma interactions

NA Bhowmick, HL Moses - Current opinion in genetics & development, 2005 - Elsevier
The importance of stromal cells and the factors that they express during cancer initiation and
progression has been highlighted by recent literature. The cellular components of the stroma …

Microenvironmental regulation of cancer development

M Hu, K Polyak - Current opinion in genetics & development, 2008 - Elsevier
Numerous studies have demonstrated that the tumor microenvironment not only responds to
and supports carcinogenesis, but also actively contributes to tumor initiation, progression …

Cancer associated fibroblasts in cancer pathogenesis

OE Franco, AK Shaw, DW Strand… - Seminars in cell & …, 2010 - Elsevier
In the past century, gradual but sustained advances in our understanding of the molecular
mechanisms involved in the growth and invasive properties of cancer cells have led to better …

Stromal involvement in malignant growth

A Van den Hooff - Advances in cancer research, 1988 - Elsevier
Publisher Summary This chapter describes various modes of interaction between malignant
cells and stroma. Malignant cells are shown to produce various lytic enzymes, which attack …

Role of stromal fibroblasts in cancer: promoting or impeding?

F Angeli, G Koumakis, MC Chen, S Kumar… - Tumor Biology, 2009 - karger.com
The basement membrane, immune cells, capillaries, fibroblasts and extracellular matrix
(ECM) constitute the tumour stroma, commonly referred to as the 'reactive stroma'. The …