Annual influenza outbreaks are associated with significant morbidity and mortality worldwide
despite the availability of seasonal vaccines. Influenza pathogenesis depends on the …

Influenza A virus (IAV) is a major human respiratory pathogen causing annual epidemics as
well as periodic pandemics. A complete understanding of the virus pathogenesis and host …

Ceramide is a lipid messenger at the heart of sphingolipid metabolism. In concert with its
metabolizing enzymes, particularly sphingomyelinases, it has key roles in regulating the …

Viruses attempt to create a distinctive cellular environment to favor viral replication and
spread. Recent studies uncovered new functions of the sphingolipid signaling/metabolism …

In this study, we show that adenoviral infection induced accumulation of the sphingolipid
ceramide in a dose-and time-dependent manner. This accumulation preceded cell lysis …

As one of the most important causative agents of severe gastroenteritis in children, piglets,
and other young animals, species A rotaviruses have adversely impacted both human …

As structural membrane components and signaling effector molecules sphingolipids
influence a plethora of host cell functions, and by doing so also the replication of viruses …

Influenza virus is an RNA virus encapsulated in a lipid bilayer derived from the host cell
plasma membrane. Previous studies showed that influenza virus infection depends on …

The cell membrane contains very small distinct membrane domains enriched of
sphingomyelin and cholesterol that are named rafts. We have shown that the formation of …

Host cell lipids play a pivotal role in the pathogenesis of respiratory virus infection. However,
a direct comparison of the lipidomic profile of influenza virus and rhinovirus infections is …