Please cite this paper as: Wathen et al.(2012) Antivirals in seasonal and pandemic influenza—
future perspectives. Influenza and Other Respiratory Viruses 7 (Suppl. 1), 76–80. Antiviral …

Viruses have evolved complex and dynamic interactions with their host cell. In recent years
we have gained insight into the expanding roles for host lipids in the virus life cycle. In …

Influenza is caused by influenza A virus (IAV), an enveloped, negative-stranded RNA virus
that derives its envelope lipids from the host cell plasma membrane. Here, we examined the …

Influenza A virus (IAV), an obligatory intracellular parasite, uses host cellular molecules to
complete its replication cycle and suppress immune responses. Proteasome subunit alpha …

Coronavirus replication is associated with intracellular membrane rearrangements in
infected cells, resulting in the formation of double-membrane vesicles (DMVs) and other …

Coronaviruses (CoVs) are emerging pathogens with a significant potential to cause life-
threatening harm to human health. Since the beginning of the 21st century, three highly …

2009 Nature America, Inc. All rights reserved. required for influenza virus replication may
also expand the number of potential targets for the development of antiviral compounds …

Over the millions of years-long co-evolution with their hosts, viruses have evolved plenty of
mechanisms through which they are able to escape cellular anti-viral defenses and utilize …

Viruses physically and metabolically remodel the host cell to establish an optimal
environment for their replication. Many of these processes involve the manipulation of lipid …

Influenza A viruses (IAVs) initiate infection by attaching Hemagglutinin (HA) on the viral
envelope to sialic acid (SA) receptors on the cell surface. Importantly, HA of human IAVs has …