Placental function and the development of fetal overgrowth and fetal growth restriction

JH Dumolt, TL Powell… - Obstetrics and Gynecology …, 2021 - obgyn.theclinics.com
The developing fetus undergoes a dynamic period of rapid growth that is responsive to
changes in the in utero environment that may contribute to the development of fetal growth …

The placenta in fetal growth restriction: what is going wrong?

C Sun, KM Groom, C Oyston, LW Chamley, AR Clark… - Placenta, 2020 - Elsevier
The placenta is essential for the efficient delivery of nutrients and oxygen from mother to
fetus to maintain normal fetal growth. Dysfunctional placental development underpins many …

[HTML][HTML] In Vitro Fertilization and Embryo Culture Strongly Impact the Placental Transcriptome in the Mouse Model

P Fauque, F Mondon, F Letourneur, MA Ripoche… - PLoS …, 2010 - journals.plos.org
Background Assisted Reproductive Technologies (ART) are increasingly used in humans;
however, their impact is now questioned. At blastocyst stage, the trophectoderm is directly in …

[HTML][HTML] Modelling human placental villous development: designing cultures that reflect anatomy

JL James, A Lissaman, YNS Nursalim… - Cellular and Molecular …, 2022 - Springer
The use of in vitro tools to study trophoblast differentiation and function is essential to
improve understanding of normal and abnormal placental development. The relative …

Bioengineering approaches for placental research

ML Wheeler, ML Oyen - Annals of Biomedical Engineering, 2021 - Springer
Research into the human placenta's complex functioning is complicated by a lack of suitable
physiological in vivo models. Two complementary approaches have emerged recently to …

[HTML][HTML] Unravelling human placental (patho-) physiology at the epigenetic and transcriptome level

A Samara, A Khalil - Frontiers in Cell and Developmental Biology, 2023 - frontiersin.org
One of the paradoxes of human development lies in its temporary dependence on an
extracorporeal organ, the placenta. The placenta is this complex entity that interfaces with …

[HTML][HTML] The programming power of the placenta

AN Sferruzzi-Perri, EJ Camm - Frontiers in physiology, 2016 - frontiersin.org
Size at birth is a critical determinant of life expectancy, and is dependent primarily on the
placental supply of nutrients. However, the placenta is not just a passive organ for the …

Sex-dependent differential transcript expression in the placenta of growth restricted infants

JL O'Callaghan, VL Clifton, P Prentis, A Ewing, Z Saif… - Placenta, 2022 - Elsevier
Introduction The pathological decrease of fetal growth during gestation can lead to
subsequent poor health outcomes for the fetus. This process is commonly controlled by the …

[HTML][HTML] Whole-transcriptome analysis delineates the human placenta gene network and its associations with fetal growth

MA Deyssenroth, S Peng, K Hao, L Lambertini… - BMC genomics, 2017 - Springer
Background The placenta is the principal organ regulating intrauterine growth and
development, performing critical functions on behalf of the developing fetus. The delineation …

Normative placental structure in pregnancy using quantitative magnetic resonance imaging

N Andescavage, K Kapse, YC Lu, SD Barnett… - Placenta, 2021 - Elsevier
Introduction To characterize normative morphometric, textural and microstructural placental
development by applying advanced and quantitative magnetic resonance imaging (qMRI) …