Deciphering the Epigenetic Landscape: Placental Development and Its Role in Pregnancy Outcomes

Y Chen, Z Ye, M Lin, L Zhu, L Xu, X Wang - Stem Cell Reviews and …, 2024 - Springer
The placenta stands out as a unique, transitory, and multifaceted organ, essential to the
optimal growth and maturation of the fetus. Functioning as a vital nexus between the …

Single-cell RNA-seq revealed diverse cell types in the mouse placenta at mid-gestation

X Zhou, Y Xu, S Ren, D Liu, N Yang, Q Han… - Experimental Cell …, 2021 - Elsevier
The mammalian placenta consists of a set of cells to ensure normal placental functions
throughout gestation. Dysfunctional placentae are considered as the origin of a series of …

Placental transcriptome co-expression analysis reveals conserved regulatory programs across gestation

S Buckberry, T Bianco-Miotto, SJ Bent, V Clifton… - BMC genomics, 2017 - Springer
Background Mammalian development in utero is absolutely dependent on proper placental
development, which is ultimately regulated by the placental genome. The regulation of the …

Placental pathologic changes associated with fetal growth restriction and consequent neonatal outcomes

D Hwa Im, YN Kim, HJ Cho, YH Park… - Fetal and Pediatric …, 2021 - Taylor & Francis
Objective To evaluate the pathological changes of the placenta to determine the mechanism
underlying placenta-derived fetal growth restriction (FGR) and investigate its influence on …

The placenta: epigenetic insights into trophoblast developmental models of a generation-bridging organ with long-lasting impact on lifelong health

M Hemberger, W Dean - Physiological Reviews, 2023 - journals.physiology.org
The placenta is a unique organ system that functionally combines both maternal and fetal
cell types with distinct lineage origins. Normal placentation is critical for developmental …

Mid-gestational gene expression profile in placenta and link to pregnancy complications

L Uusküla, J Männik, K Rull, A Minajeva, S Koks… - PLoS …, 2012 - journals.plos.org
Despite the importance of placenta in mediating rapid physiological changes in pregnancy,
data on temporal dynamics of placental gene expression are limited. We completed the first …

Revealing the molecular landscape of human placenta: a systematic review and meta-analysis of single-cell RNA sequencing studies

E Derisoud, H Jiang, A Zhao… - Human …, 2024 - academic.oup.com
BACKGROUND With increasing significance of developmental programming effects
associated with placental dysfunction, more investigations are devoted to improving the …

Adaptability and potential for treatment of placental functions to improve embryonic development and postnatal health

JC Cross - Reproduction, Fertility and Development, 2016 - CSIRO Publishing
For an organ that is so critical for life in eutherian mammals, the placenta hardly gets the
attention that it deserves. The placenta does a series of remarkable things, including …

Mapping cell-to-tissue graphs across human placenta histology whole slide images using deep learning with HAPPY

C Vanea, J Džigurski, V Rukins, O Dodi… - Nature …, 2024 - nature.com
Accurate placenta pathology assessment is essential for managing maternal and newborn
health, but the placenta's heterogeneity and temporal variability pose challenges for …

IFPA Meeting 2012 Workshop Report I: comparative placentation and animal models, advanced techniques in placental histopathology, human pluripotent stem cells …

WE Ackerman IV, AM Carter, AM De Mestre, TG Golos… - Placenta, 2013 - Elsevier
Workshops are an important part of the IFPA annual meeting as they allow for discussion of
specialized topics. At IFPA meeting 2012 there were twelve themed workshops, three of …