✓ Tumor tissue from seven human gliomas was maintained in long-term agar overlay culture
as multicellular organotypic spheroids. Light microscopic and ultrastructural observation of …

Object. The aim of this study was to develop an improved animal model for brain tumor
study. The need for better and more relevant brain tumor models is generally acknowledged …

Tumor spheroids were cultured from five human glioma cell lines which differed
considerably in their relative amount and composition of glycosaminoglycans (GAG) …

Light microscopy observations are described on five human glioblastomas grown in organ
culture systems, using either a three-dimensional sponge foam matrix technic or a Millipore …

A new technique, based on the growth of tumor cells in liquid media over an agar base, has
been developed for the formation and growth of multicellular tumor spheroids. All of the 11 …

Background: The use of three-dimensional in vitro models of brain tumor invasion has
provided a system for reconstructing some of the cellular microenvironments present in the …

The purpose of the meeting was to exchange information on spheroid culture methods and
to review the role of spheroids in cancer research. Techniques and results presented at this …

Multicellular tumor spheroids (MTS) from seven murine solid tumors have been compared in
terms of their growth rate and the fraction of the cells that are in cycle. Growth rates ranged …

During the last three decades multicellular spheroids of both normal and malignant cells
have been used as model systems for studying three-dimen sional growth and differentiation …

The invasiveness of human intracranial tumours was studied in an organ culture system.
Biopsies from six glioblastomas, four astrocytomas, two mixed gliomas, one ependymoma …