Background: Asthma is associated with increased production of IL-4 and IL-13. Objective:
Because many of the effects of these cytokines are mediated by activation of signal …

Activation of IL-4R (IL-4 receptor) signaling in airway epithelial cells leads to airway
hyperresponsiveness and mucus overproduction in asthma. CDH26 (cadherin-26), a …

Atopy and autoimmunity are usually considered opposed immunological manifestations.
Lyn−/− mice develop lupus-like autoimmune disease yet have coexistent intrinsic allergic …

Background: Stat3, Socs3 and cytokines play an integral role in the coordination and
persistence of inflammation. However, a clear understanding of the role played by the …

Background Type 2 T helper lymphocytes (Th2 cells) and their cytokine products are
important in the pathogenesis of asthma. Objective To examine the contribution of the signal …

Bronchial asthma is a heterogeneous chronic inflammatory disease of airways. The studies
of molecular and cellular mechanisms of bronchial asthma have established that a wide …

Because cysteinyl-leukotrienes (cysLTs) are major protagonists in the pathophysiology of
human asthma, and because neutrophils are involved in the more severe form of asthma …

Background The molecular determinants of the severity and persistence of allergic asthma
remain poorly understood. Suppressor of cytokine signalling 1 (SOCS1) is a negative …

Background Asthma is characterised by increased numbers of Th2-like cells in the airways
and IgE secretion. Generation of Th2 cells requires interleukin (IL)-4 and IL-13 acting …

New Findings What is the central question of this study? Airway angiogenesis occurs in
asthma, and airway smooth muscle (ASM) cells have been reported to be capable of …